Analysis Tools
respiratory system
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• reduced olfactory receptor neurons (ORNs) layer thickness beginning at 28 days after doxycycline treatment
• markedly abnormal reduction of the ORN layer at 35 days after doxycycline treatment
• rapid and essentially complete loss of neuronal cells and their corresponding axons at 42 days after doxycycline treatment
• the epithelium consists primarily of apical sustentacular cells and basal progenitors at 42 days after doxycycline treatment
• by 14 days after doxycycline withdrawal, the ORNs are extensively regenerated and there is nearly normal axon bundle morphology
• at 28 days after doxycycline withdrawal, the ORN layer is indistinguishable from untreated mice
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• reduced olfactory receptor neurons (ORNs) layer thickness beginning at 28 days after doxycycline treatment
• markedly abnormal reduction of the ORN layer at 35 days after doxycycline treatment
• rapid and essentially complete loss of neuronal cells and their corresponding axons at 42 days after doxycycline treatment
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• inflammatory infiltrate and indistinct axon bundles in the subepithelium at approximately day 21
• dense infiltration of inflammatory cells and an absence of discernable axon bundles in the subepithelium at 42 days after doxycycline treatment
• numerous macrophages in the subepithelium by anti-CD68 immunostaining at 42 days after doxycycline treatment
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nervous system
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• reduced olfactory receptor neurons (ORNs) layer thickness beginning at 28 days after doxycycline treatment
• markedly abnormal reduction of the ORN layer at 35 days after doxycycline treatment
• rapid and essentially complete loss of neuronal cells and their corresponding axons at 42 days after doxycycline treatment
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taste/olfaction
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• reduced olfactory receptor neurons (ORNs) layer thickness beginning at 28 days after doxycycline treatment
• markedly abnormal reduction of the ORN layer at 35 days after doxycycline treatment
• rapid and essentially complete loss of neuronal cells and their corresponding axons at 42 days after doxycycline treatment
• the epithelium consists primarily of apical sustentacular cells and basal progenitors at 42 days after doxycycline treatment
• by 14 days after doxycycline withdrawal, the ORNs are extensively regenerated and there is nearly normal axon bundle morphology
• at 28 days after doxycycline withdrawal, the ORN layer is indistinguishable from untreated mice
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• reduced olfactory receptor neurons (ORNs) layer thickness beginning at 28 days after doxycycline treatment
• markedly abnormal reduction of the ORN layer at 35 days after doxycycline treatment
• rapid and essentially complete loss of neuronal cells and their corresponding axons at 42 days after doxycycline treatment
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• absent odorant-induced electroolfactogram (EOG) amplitudes after 42 days on doxycycline
• the EOG amplitudes return to normal at 14 days after doxycycline withdrawal
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• reduced (60%) odorant-induced electroolfactogram (EOG) amplitudes after 14 days on doxycycline
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cellular
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• no increase in proliferation shown by BrdU staining when the olfactory receptor neurons depleted after doxycycline treatment
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immune system
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• numerous macrophages in the olfactory subepithelium by anti-CD68 immunostaining at 42 days after doxycycline treatment
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• inflammatory infiltrate and indistinct axon bundles in the subepithelium at approximately day 21
• dense infiltration of inflammatory cells and an absence of discernable axon bundles in the subepithelium at 42 days after doxycycline treatment
• numerous macrophages in the subepithelium by anti-CD68 immunostaining at 42 days after doxycycline treatment
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hematopoietic system
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• numerous macrophages in the olfactory subepithelium by anti-CD68 immunostaining at 42 days after doxycycline treatment
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craniofacial
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• reduced olfactory receptor neurons (ORNs) layer thickness beginning at 28 days after doxycycline treatment
• markedly abnormal reduction of the ORN layer at 35 days after doxycycline treatment
• rapid and essentially complete loss of neuronal cells and their corresponding axons at 42 days after doxycycline treatment
• the epithelium consists primarily of apical sustentacular cells and basal progenitors at 42 days after doxycycline treatment
• by 14 days after doxycycline withdrawal, the ORNs are extensively regenerated and there is nearly normal axon bundle morphology
• at 28 days after doxycycline withdrawal, the ORN layer is indistinguishable from untreated mice
|
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• reduced olfactory receptor neurons (ORNs) layer thickness beginning at 28 days after doxycycline treatment
• markedly abnormal reduction of the ORN layer at 35 days after doxycycline treatment
• rapid and essentially complete loss of neuronal cells and their corresponding axons at 42 days after doxycycline treatment
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growth/size/body
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• reduced olfactory receptor neurons (ORNs) layer thickness beginning at 28 days after doxycycline treatment
• markedly abnormal reduction of the ORN layer at 35 days after doxycycline treatment
• rapid and essentially complete loss of neuronal cells and their corresponding axons at 42 days after doxycycline treatment
• the epithelium consists primarily of apical sustentacular cells and basal progenitors at 42 days after doxycycline treatment
• by 14 days after doxycycline withdrawal, the ORNs are extensively regenerated and there is nearly normal axon bundle morphology
• at 28 days after doxycycline withdrawal, the ORN layer is indistinguishable from untreated mice
|
|
• reduced olfactory receptor neurons (ORNs) layer thickness beginning at 28 days after doxycycline treatment
• markedly abnormal reduction of the ORN layer at 35 days after doxycycline treatment
• rapid and essentially complete loss of neuronal cells and their corresponding axons at 42 days after doxycycline treatment
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| sinusitis | DOID:0050127 | J:157842 | ||
