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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Fabp4-LEP)F8Ffc
transgene insertion F8, Farid F Chehab
MGI:4437889
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Fabp4-LEP)F8Ffc/0 involves: C57BL/6J * DBA/2J MGI:4437897
tg2
Tg(Fabp4-LEP)F8Ffc/? B6.Cg-Tg(Fabp4-LEP)F8Ffc MGI:5297914


Genotype
MGI:4437897
tg1
Allelic
Composition
Tg(Fabp4-LEP)F8Ffc/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• at 6 to 9 weeks, brown fat adipocytes are devoid of lipid droplets unlike in wild-type mice
• however, by 36 weeks brown fat adipocytes appear normal
• at 6 to 9 weeks, white fat adipocytes contain few lipid droplets unlike in wild-type mice
• however, by 36 weeks white fat adipocytes appear normal
• at 6 to 9 weeks, fat pads (such as pericardial, perirenal, mesenteric, and sc fat depots) are absent or too minute to weigh unlike in wild-type mice
• however, at 33 to 36 weeks fat pad weights are normal
• young mice, but not old mice, exhibit a decrease or absence in gonadal white adipose tissue compared with wild-type mice
• at 6 to 9 weeks, brown and white gonadal adipose tissue is reduced 4.2- and 2.6-fold, respectively, compared with wild-type mice
• gonadal white adipose tissue weighs 13.8- and 8.7-fold less in male and female mice, respectively, than in wild-type mice
• at 6 to 9 weeks, mice exhibit a reduction in brown adipose tissue and absence of white adipose tissue in the interscapular region unlike wild-type mice
• however, by 33 to 36 weeks no interscapular depression is observed

homeostasis/metabolism
• at 6 to 9 weeks, cold exposed male and female mice exhibit a drop in body temperature within 6 to 9 hours and 2 to 22 hours, respectively, unlike similarly treated wild-type mice
• however, mice exhibit normal body temperature regulation at 33 to 36 weeks or in young mice fed a high fat diet
• at 6 to 9 weeks, plasma insulin levels are 4- and 3-fold less in males and female mice, respectively, compared with wild-type mice
• at 33 to 36 weeks, plasma insulin levels are 2.7-fold lower in male, but not female, mice compared to in wild-type mice
• at 6 to 9 weeks and 33 to 36 weeks, male mice exhibit a 4- and 4.9-fold, respectively, increased over endogenous levels
• at 6 to 9 weeks and 33 to 36 weeks, female mice exhibit a 2.5- and 4.2-fold, respectively, increased over endogenous levels
• at 6 to 9 weeks, plasma triglyceride levels are 2- and 3-fold lower in males and female mice, respectively, compared with wild-type mice

growth/size/body
• body weight distribution shifts leftward of the bell-shaped curves of transgenic versus nontransgenic mice
• young mice exhibit a decrease in carcass weight compared with wild-type mice that accounts for differences in body weight

liver/biliary system
• 1.4-fold in young mice

behavior/neurological
• at a young age but not at 33 to 36 weeks




Genotype
MGI:5297914
tg2
Allelic
Composition
Tg(Fabp4-LEP)F8Ffc/?
Genetic
Background
B6.Cg-Tg(Fabp4-LEP)F8Ffc
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• lower body weight on a normal chow diet through 40 weeks of age
• gain weight 1.6 times faster than controls on a high fat diet

adipose tissue
• increases 52% on a high fat diet compared to control mice
• other fat depots are similar to controls on a high fat diet
• reduced 95% at 9 weeks of age on a chow diet
• small epididymal mass and no other detectable fat depots
• white adipose tissue adipocytes are 76% smaller than controls on a normal chow diet
• white adipocytes are hypertrophied about 22% on a high fat diet relative to controls
• small epididymal mass and no other detectable fat depots

homeostasis/metabolism
• leptin levels are elevated regardless of diet
• reduced 76% on a normal chow diet compared to controls
• levels are normal on a high fat diet
• insulin levels increase 10.7 fold on a high fat diet compared to a 2.2 fold increase for controls
• reduced 33% on a normal chow diet
• levels are normal on a high fat diet

integument
• increases 52% on a high fat diet compared to control mice
• other fat depots are similar to controls on a high fat diet

endocrine/exocrine glands
• insulin levels increase 10.7 fold on a high fat diet compared to a 2.2 fold increase for controls





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory