Analysis Tools
behavior/neurological
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• locomotor function, baseline startle response, pain sensitivity and prepulse inhibition are similar to controls
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• mice show robust attenuation of freezing when presented with the conditioned stimulus (tone) when tested for expression of previously learned fear
• mice show deficits in short- and long-term learning and memory to the conditioned cue, but display normal rate of extinction of conditioned fear
• 7,8-Dihydroxyflavone treatment rescues this impairment in cued fear conditioning
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