Analysis Tools
mortality/aging
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• females display a marked increase in mortality; females begin to die at 17 weeks of age and all females are dead by 30 weeks
• death in most animals is infiltration of endometrial cancer into the urinary bladder
• 4 weeks of daily rapamycin treatment (started around 30 weeks) extended lifespan to 36 weeks+ compared to untreated control mutants
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neoplasm
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• endometrial carcinoma spreads to adjacent organs in older animals
• distant metastases (such as pulmonary or subcutaneous nodules) are observed infrequently
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• female mortality results from invasive endometrial cancers
• tumor infiltration is progressive throughout the uteri resulting in diffuse uterine enlargement with increasing age
• uteri develop normally and are normal in size through onset of sexual maturity, but by 16 weeks of age there is significant uterine enlargement; in females surviving to 28 weeks, the average uterine weight is increased around 10 fold relative to controls
• by 12 weeks of age, diffuse infiltration of the myometrium is observed in most animals
• in older animals endometrial carcinoma spreads to adjacent organs, most significantly the ovary, cervix and bladder
• daily intraperitoneal rapamycin injections for 4 weeks (started around 30 weeks) slowed significantly slowed progression, resulting in 2.4 fold decrease in mean uterine weights; tumor burden is reduced and increased apoptotic cell death is detected in endometrial epithelial cells
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reproductive system
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• female mortality results from invasive endometrial cancers
• tumor infiltration is progressive throughout the uteri resulting in diffuse uterine enlargement with increasing age
• uteri develop normally and are normal in size through onset of sexual maturity, but by 16 weeks of age there is significant uterine enlargement; in females surviving to 28 weeks, the average uterine weight is increased around 10 fold relative to controls
• by 12 weeks of age, diffuse infiltration of the myometrium is observed in most animals
• in older animals endometrial carcinoma spreads to adjacent organs, most significantly the ovary, cervix and bladder
• daily intraperitoneal rapamycin injections for 4 weeks (started around 30 weeks) slowed significantly slowed progression, resulting in 2.4 fold decrease in mean uterine weights; tumor burden is reduced and increased apoptotic cell death is detected in endometrial epithelial cells
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• by 12 weeks of age, diffuse infiltration of the myometrium is observed in most animals
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• uteri develop normally and are normal in size through onset of sexual maturity, but by 16 weeks of age there is significant uterine enlargement; in females surviving to 28 weeks, the average uterine weight is increased around 10 fold relative to controls
• tumor infiltration is progressive throughout the uteri resulting in diffuse uterine enlargement with increasing age
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• by 16 weeks of age, there is significant uterine enlargement and in
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renal/urinary system
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• results from infiltration of endometrial carcinoma into the bladder
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• uteri develop normally and are normal in size through onset of sexual maturity, but by 16 weeks of age there is significant uterine enlargement; in females surviving to 28 weeks, the average uterine weight is increased around 10 fold relative to controls
• tumor infiltration is progressive throughout the uteri resulting in diffuse uterine enlargement with increasing age
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• urinary tract obstruction result from tumor infiltration into the bladder
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digestive/alimentary system
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• invasion through uterine wall results in peritonitis in some animals, contributing to morbity
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immune system
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• invasion through uterine wall results in peritonitis in some animals, contributing to morbity
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• invasion through uterine wall results in sepsis in some animals, contributing to morbity
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| endometrial cancer | DOID:1380 |
OMIM:608089 |
J:158190 | |
