All Phenotypes Col8a2<Aca23> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Col8a2^Aca23
ACMaster abnormality 23
MGI:4438451

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Col8a2^Aca23/Col8a2^Aca23	C57BL/6J-Col8a2^Aca23	MGI:4438460
ht2	Col8a2^Aca23/Col8a2⁺	C57BL/6J-Col8a2^Aca23	MGI:4438459

Allelic Composition	Col8a2^Aca23/Col8a2^Aca23
Genetic Background	C57BL/6J-Col8a2^Aca23

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col8a2^Aca23 mutation (1 available); any Col8a2 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:158259 )

N	• corneas do not develop opacities and remain transparent at least until 15 months • mice exhibit normal corneal epithelium proliferation, eye fundus, and visual acuity

abnormal eye morphology ( J:158259 )

• eye abnormalities are more severe than in heterozygotes

• mice exhibit enlarged axis compared with wild-type mice

decreased Descemet membrane thickness ( J:158259 )

• reduced Descemet's membrane thickness

abnormal cornea epithelium morphology ( J:158259 )

• mice exhibit reduced epithelium compared with wild-type mice

decreased cornea thickness ( J:158259 )

decreased cornea stroma thickness ( J:158259 )

abnormal eye anterior chamber morphology ( J:158259 )

• contains globoid, keratoglobus-like protrusion

enlarged eye anterior chamber ( J:158259 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Fuchs' endothelial dystrophy	DOID:11555	OMIM:136800 OMIM:610158 OMIM:613267 OMIM:613268 OMIM:613269 OMIM:613270 OMIM:613271 OMIM:615523	J:158259

Allelic Composition	Col8a2^Aca23/Col8a2⁺
Genetic Background	C57BL/6J-Col8a2^Aca23

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col8a2^Aca23 mutation (1 available); any Col8a2 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:158259 )

N	• corneas do not develop opacities and remain transparent at least until 15 months • mice exhibit normal corneal epithelium proliferation, eye fundus, and visual acuity

abnormal eye morphology ( J:158259 )

• eye abnormalities are less severe than in homozygotes

• mice exhibit enlarged axis compared with wild-type mice

decreased Descemet membrane thickness ( J:158259 )

• reduced Descemet's membrane thickness

abnormal cornea epithelium morphology ( J:158259 )

• mice exhibit reduced epithelium compared with wild-type mice

decreased cornea thickness ( J:158259 )

decreased cornea stroma thickness ( J:158259 )

abnormal eye anterior chamber morphology ( J:158259 )

• contains globoid, keratoglobus-like protrusion

enlarged eye anterior chamber ( J:158259 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Fuchs' endothelial dystrophy	DOID:11555	OMIM:136800 OMIM:610158 OMIM:613267 OMIM:613268 OMIM:613269 OMIM:613270 OMIM:613271 OMIM:615523	J:158259

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24