Analysis Tools
mortality/aging
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• mice begin to die between E10.5 and E12.5 with none present at birth
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• mice begin to die between E10.5 and E12.5 with none present at birth
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nervous system
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• at E11.5, mice exhibit an increase in apoptotic cells in the brain compared to in wild-type mice
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• at E9.5 to E11.5, the neural tube cell layer is thinner than in wild-type mice
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cellular
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• mouse embryonic fibroblasts exhibit clustered perinuclear mitochondria with extended tubules unlike in wild-type cells
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• at E12.5, mitochondria are enlarged compared to in wild-type mice
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• mouse embryonic fibroblasts exhibit elongated or swollen peroxisomes unlike in wild-type cells
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• at E11.5, mice exhibit an increase in apoptotic cells in the brain compared to in wild-type mice
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• slightly in mouse embryonic fibroblasts
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embryo
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• at E9.5 to E11.5
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• at E9.5 to E11.5, the neural tube cell layer is thinner than in wild-type mice
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cardiovascular system
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• at E9.5 to E11.5, cardiac structures are underdeveloped compared to in wild-type mice
• however, cardiac structures do pulse
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liver/biliary system
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• at E9.5 to E11.5
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growth/size/body
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• at E9.5 to E11.5
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