Phenotypes associated with this allele

• Allele Symbol: Dagla^tm1Pado
• Allele Name: targeted mutation 1, Patrick Doherty
• Allele ID: MGI:4438719
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dagla^tm1Pado/Dagla^tm1Pado	C57BL/6-Dagla^tm1Pado	MGI:4438725
ht2	Dagla^tm1Pado/Dagla^+	C57BL/6-Dagla^tm1Pado	MGI:4438724

Genotype
MGI:4438725

hm1

• Allelic Composition: Dagla^tm1Pado/Dagla^tm1Pado
• Genetic Background: C57BL/6-Dagla^tm1Pado

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:157850 )

• Depolarization induced suppression of inhibition is entirely absent in CA1 neurons

• a slight increase of evoked IPSC amplitude post depolarization is observed

homeostasis/metabolism

abnormal lipid level ( J:157850 )

• in adult brain and spinal cord, 80% reduction in 2-arachidonoyl-glycerol (2-AG), an endocannabinoid

• about a 60% reduction in 2-AG in the liver

• 40% decrease of N-arachidonoylethanolamine in the brain

• about an 80% reduction in arachidonic acid levels in the brain

nervous system

abnormal neuron proliferation ( J:157850 )

• significant reductions in proliferation in subventricular zone and hippocampus at 7 - 10 weeks of age

decreased neuronal precursor cell number ( J:157850 )

• 50% reduction in neuroblasts in subventricular zone at 7 - 10 weeks of age

abnormal inhibitory postsynaptic currents ( J:157850 )

cellular

abnormal neuron proliferation ( J:157850 )

• significant reductions in proliferation in subventricular zone and hippocampus at 7 - 10 weeks of age

Genotype
MGI:4438724

ht2

• Allelic Composition: Dagla^tm1Pado/Dagla⁺
• Genetic Background: C57BL/6-Dagla^tm1Pado

nervous system

abnormal neuron proliferation ( J:157850 )

• significant reduction in proliferation in subventricular zone at 7 - 10 weeks of age

cellular

abnormal neuron proliferation ( J:157850 )

• significant reduction in proliferation in subventricular zone at 7 - 10 weeks of age