Phenotypes associated with this allele

• Allele Symbol: Kdm3a^tm1.1Jsak
• Allele Name: targeted mutation 1.1, Juro Sakai
• Allele ID: MGI:4438720
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kdm3a^tm1.1Jsak/Kdm3a^tm1.1Jsak	involves: C57BL/6 * CBA	MGI:4438732

Genotype
MGI:4438732

hm1

• Allelic Composition: Kdm3a^tm1.1Jsak/Kdm3a^tm1.1Jsak
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired adaptive thermogenesis ( J:158258 )

• mice fasted for 12 hours are hypothermic mice unlike similarly treated wild-type mice

increased circulating glucose level ( J:158258 )

• in fed mice at 9 to 15 weeks of age

increased circulating insulin level ( J:158258 )

• in fed and fasted male mice at 9 to 15 weeks of age

• in glucose-stimulated mice at 9 to 11 weeks of age

increased circulating leptin level ( J:158258 )

• in fed mice at 9 to 15 weeks of age

increased circulating cholesterol level ( J:158258 )

• in fed and fasted mice at 9 to 15 weeks of age

increased circulating triglyceride level ( J:158258 )

• in fed and fasted male mice at 9 to 15 weeks of age

increased respiratory quotient ( J:158258 )

• higher in the dark cycle than in wild-type mice

insulin resistance ( J:158258 )

• at 10 to 12 weeks of age, insulin-stimulated mice exhibit increased circulating glucose levels compared with similarly treated wild-type mice

adipose tissue

increased fat cell size ( J:158258 )

increased epididymal fat pad weight ( J:158258 )

• white adipose tissue weight is increased compared to in wild-type mice

increased retroperitoneal fat pad weight ( J:158258 )

• white adipose tissue weight is increased compared to in wild-type mice

abnormal white adipose tissue morphology ( J:158258 )

• white adipose tissue is hypertrophic compared to in wild-type mice

increased white adipose tissue amount ( J:158258 )

• mice exhibit increased weights of epididymal, retroperitoneal, and mesenteric white adipose tissue compared with wild-type mice

growth/size/body

obese ( J:158258 )

• mice exhibit adult onset obesity unlike wild-type mice

increased susceptibility to weight gain ( J:158258 )

• after 12 weeks of age