Phenotypes associated with this allele

• Allele Symbol: Cd84^tm1Pls
• Allele Name: targeted mutation 1, Pamela L Schwartzberg
• Allele ID: MGI:4438772
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd84^tm1Pls/Cd84^tm1Pls	C57BL/6J-Cd84^tm1Pls	MGI:4438776
cx2	Cd84^tm1Pls/Cd84^tm1Pls Tg(TcraTcrb)425Cbn/?	B6.Cg-Cd84^tm1Pls Tg(TcraTcrb)425Cbn	MGI:4438779

Genotype
MGI:4438776

hm1

• Allelic Composition: Cd84^tm1Pls/Cd84^tm1Pls
• Genetic Background: C57BL/6J-Cd84^tm1Pls

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased germinal center B cell number ( J:157915 )

• 9 days after immunization with a T cell dependent antigen, 4-hydroxy-3-nitrophenyl acetyl(NP) -OVA, mice have reduced numbers of B220+ IgD^lo Fas^hi GL-7+ germinal center B cells

decreased CD4-positive, alpha-beta T cell number ( J:157915 )

• 7-9 days after immunization, there is a decrease in CD4+ T cells expressing Tfh cell markers

abnormal long lived plasma cell morphology ( J:157915 )

• fewer 4-hydroxy-3-nitrophenyl acetyl(NP)-OVA specific antibody secreting cells in the bone marrow 30 days postimmunization

decreased spleen germinal center size ( J:157915 )

• 9 days after immunization with a T cell dependent antigen, 4-hydroxy-3-nitrophenyl acetyl(NP) -OVA, mice have fewer germinal center structures that are also reduced in size

decreased IgG level ( J:157915 )

• high-affinity 4-hydroxy-3-nitrophenyl acetyl(NP) specific antibodies are at lower titers than in wild-type mice, 30 days postimmunization

abnormal CD4-positive, alpha-beta T cell physiology ( J:157915 )

• after immunization with the T-dependent antigen 4-hydroxy-3-nitrophenyl acetyl(NP) fewer cells produce IL21

immune system

decreased germinal center B cell number ( J:157915 )

• 9 days after immunization with a T cell dependent antigen, 4-hydroxy-3-nitrophenyl acetyl(NP) -OVA, mice have reduced numbers of B220+ IgD^lo Fas^hi GL-7+ germinal center B cells

decreased CD4-positive, alpha-beta T cell number ( J:157915 )

• 7-9 days after immunization, there is a decrease in CD4+ T cells expressing Tfh cell markers

abnormal long lived plasma cell morphology ( J:157915 )

• fewer 4-hydroxy-3-nitrophenyl acetyl(NP)-OVA specific antibody secreting cells in the bone marrow 30 days postimmunization

decreased spleen germinal center size ( J:157915 )

• 9 days after immunization with a T cell dependent antigen, 4-hydroxy-3-nitrophenyl acetyl(NP) -OVA, mice have fewer germinal center structures that are also reduced in size

decreased IgG level ( J:157915 )

• high-affinity 4-hydroxy-3-nitrophenyl acetyl(NP) specific antibodies are at lower titers than in wild-type mice, 30 days postimmunization

abnormal CD4-positive, alpha-beta T cell physiology ( J:157915 )

• after immunization with the T-dependent antigen 4-hydroxy-3-nitrophenyl acetyl(NP) fewer cells produce IL21

decreased interleukin-21 secretion ( J:157915 )

• from mice immunized with the T-dependent antigen -OVA

Genotype
MGI:4438779

cx2

• Allelic Composition: Cd84^tm1Pls/Cd84^tm1Pls; Tg(TcraTcrb)425Cbn/?
• Genetic Background: B6.Cg-Cd84^tm1Pls Tg(TcraTcrb)425Cbn

immune system

abnormal CD4-positive, alpha-beta T cell physiology ( J:157915 )

• when B cells are used as the antigen presenting cells, T cells are significantly less efficient in forming conjugates as compared to their wild-type counterparts

hematopoietic system

abnormal CD4-positive, alpha-beta T cell physiology ( J:157915 )

• when B cells are used as the antigen presenting cells, T cells are significantly less efficient in forming conjugates as compared to their wild-type counterparts