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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adam10tm1.1Dhc
targeted mutation 1.1, Daniel H Conrad
MGI:4438892
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Adam10tm1.1Dhc/Adam10tm1.1Dhc
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL MGI:4438893


Genotype
MGI:4438893
cn1
Allelic
Composition		 Adam10tm1.1Dhc/Adam10tm1.1Dhc
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10tm1.1Dhc mutation (0 available); any Adam10 mutation (38 available)
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:158127 )
• severely abrogated development of precursors to MZBs in the spleen
decreased transitional stage T2 B cell number ( J:158127 )
• decreased level of T2 B cells in the spleen
increased transitional stage T1 B cell number ( J:158127 )
• modestly increased percentage of T1 cells in the spleen compared with heterozygotes
• normal percentage of total B cells
absent marginal zone B cells ( J:158127 )
• absent marginal zone B cell (MZB) lineage in the spleen
• complete absence of MZBs surrounding the marginal sinus, labeled with the metallophilic macrophage marker 1 in the spleen
increased follicular B cell number ( J:158127 )
• increased level of follicular B cells in the spleen

immune system
abnormal B cell differentiation ( J:158127 )
• severely abrogated development of precursors to MZBs in the spleen
decreased transitional stage T2 B cell number ( J:158127 )
• decreased level of T2 B cells in the spleen
increased transitional stage T1 B cell number ( J:158127 )
• modestly increased percentage of T1 cells in the spleen compared with heterozygotes
• normal percentage of total B cells
absent marginal zone B cells ( J:158127 )
• absent marginal zone B cell (MZB) lineage in the spleen
• complete absence of MZBs surrounding the marginal sinus, labeled with the metallophilic macrophage marker 1 in the spleen
increased follicular B cell number ( J:158127 )
• increased level of follicular B cells in the spleen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory