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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nr2f1tm2.1Mjts
targeted mutation 2.1, Ming-Jer Tsai
MGI:4439069
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts
Tg(rx3-icre)1Mjam/0 		involves: 129 MGI:4439070
cn2
 		Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts
Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Tg(rx3-icre)1Mjam/0 		involves: 129S7/SvEvBrd MGI:4439072
cn3
 		Nr2f1tm2.1Mjts/Nr2f1+
Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Tg(rx3-icre)1Mjam/0 		involves: 129S7/SvEvBrd MGI:4439073
cn4
 		Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts
Nr2f2tm2.1Tsa/Nr2f2+
Tg(rx3-icre)1Mjam/0 		involves: 129S7/SvEvBrd MGI:4439074


Genotype
MGI:4439070
cn1
Allelic
Composition		 Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts
Tg(rx3-icre)1Mjam/0
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2f1tm2.1Mjts mutation (1 available); any Nr2f1 mutation (25 available)
Tg(rx3-icre)1Mjam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:157924 )
N
• no gross defects in eye development are detected




Genotype
MGI:4439072
cn2
Allelic
Composition		 Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts
Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Tg(rx3-icre)1Mjam/0
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2f1tm2.1Mjts mutation (1 available); any Nr2f1 mutation (25 available)
Nr2f2tm2.1Tsa mutation (0 available); any Nr2f2 mutation (28 available)
Tg(rx3-icre)1Mjam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
absent optic disk ( J:157924 )
• not detected at E14.5
abnormal retina pigment epithelium morphology ( J:157924 )
• at E11.5 and E14.5 expression analysis indicates that proximo-ventral cells in the presumptive retinal pigment epithelium possess neural retinal identity
• however, nasal-dorsal cells retain their retinal pigment epithelium identity
abnormal eye development ( J:157924 )
• at E11.5 expression analysis indicates that progenitor cells in the distal ventral optic stalk gain a neural retinal identity
• at E14.5 a neural retina like structure connects directly with the diencephalon
• at E14.5 expression analysis indicates that proximo-ventral cells in the presumptive retinal pigment epithelium possess neural retinal identity
abnormal optic stalk morphology ( J:157924 )
• at E10.5 the optic stalk resembles the early (E9.5) optic vesicle
• at E12.5 and E14.5 the optic stalk is open ventrally
• the ventral optic stalk is not detected by morphology at E14.5
• however, expression analysis indicates optic stalk identity is maintained but that the boundary between the stalk and neural retina is shifted proximally
• expression analysis indicates that differentiation of dorsal optic stalk cells is impaired
coloboma ( J:157924 )
• severe at E14.5
• at E12.5 and E14.5 the optic stalk is open ventrally
microphthalmia ( J:157924 )
• seen at E14.5 and persists through birth

nervous system
absent optic disk ( J:157924 )
• not detected at E14.5

pigmentation
abnormal retina pigment epithelium morphology ( J:157924 )
• at E11.5 and E14.5 expression analysis indicates that proximo-ventral cells in the presumptive retinal pigment epithelium possess neural retinal identity
• however, nasal-dorsal cells retain their retinal pigment epithelium identity




Genotype
MGI:4439073
cn3
Allelic
Composition		 Nr2f1tm2.1Mjts/Nr2f1+
Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Tg(rx3-icre)1Mjam/0
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2f1tm2.1Mjts mutation (1 available); any Nr2f1 mutation (25 available)
Nr2f2tm2.1Tsa mutation (0 available); any Nr2f2 mutation (28 available)
Tg(rx3-icre)1Mjam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
coloboma ( J:157924 )
• bilaterally open optic fissure at E14.5




Genotype
MGI:4439074
cn4
Allelic
Composition		 Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts
Nr2f2tm2.1Tsa/Nr2f2+
Tg(rx3-icre)1Mjam/0
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2f1tm2.1Mjts mutation (1 available); any Nr2f1 mutation (25 available)
Nr2f2tm2.1Tsa mutation (0 available); any Nr2f2 mutation (28 available)
Tg(rx3-icre)1Mjam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
coloboma ( J:157924 )
• bilaterally open optic fissure at E14.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory