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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itga6tm2Egl
targeted mutation 2, Elisabeth Georges-Labouesse
MGI:4439081
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Itga3tm1Hap/Itga3tm1Hap
Itga6tm2Egl/Itga6tm2Egl
Tg(Mpz-cre)26Mes/0 		involves: 129 * C57BL/6 * FVB/NTac MGI:5563094
cn2
 		Itga6tm2Egl/Itga6tm2Egl
Tg(Tie1-cre)9Ref/0 		involves: 129S1/Sv * 129X1/SvJ MGI:4439082
cn3
 		Itga6tm2Egl/Itga6tm2Egl
Itga7tm1Umr/Itga7tm1Umr
Tg(Mpz-cre)26Mes/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac MGI:5563096
cn4
 		Itga6tm2Egl/Itga6tm2Egl
Tg(Mpz-cre)26Mes/0 		involves: C57BL/6 * FVB/NTac MGI:5563093


Genotype
MGI:5563094
cn1
Allelic
Composition		 Itga3tm1Hap/Itga3tm1Hap
Itga6tm2Egl/Itga6tm2Egl
Tg(Mpz-cre)26Mes/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga3tm1Hap mutation (0 available); any Itga3 mutation (53 available)
Itga6tm2Egl mutation (0 available); any Itga6 mutation (211 available)
Tg(Mpz-cre)26Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:204174 )
N
• normal morphology of sciatic nerves and spinal roots with no gross defects in axon sorting and myelination




Genotype
MGI:4439082
cn2
Allelic
Composition		 Itga6tm2Egl/Itga6tm2Egl
Tg(Tie1-cre)9Ref/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga6tm2Egl mutation (0 available); any Itga6 mutation (211 available)
Tg(Tie1-cre)9Ref mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor vascularization ( J:156496 )
• injected cell derived tumors display increased blood vessel density
increased tumor growth/size ( J:156496 )
• increase in tumor size 10 - 12 days after injection of Lewis lung carcinoma or murine melanoma cells compared to controls

cardiovascular system
abnormal tumor vascularization ( J:156496 )
• injected cell derived tumors display increased blood vessel density
increased angiogenesis ( J:156496 )
• increase in vessel growth into implanted VEGF treated sponges and enhanced VEGF induced micro vessel sprouting in vitro compared to controls
• however, vessel density in untreated skin is not different from controls




Genotype
MGI:5563096
cn3
Allelic
Composition		 Itga6tm2Egl/Itga6tm2Egl
Itga7tm1Umr/Itga7tm1Umr
Tg(Mpz-cre)26Mes/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga6tm2Egl mutation (0 available); any Itga6 mutation (211 available)
Itga7tm1Umr mutation (0 available); any Itga7 mutation (35 available)
Tg(Mpz-cre)26Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon radial sorting ( J:204174 )
• delay in radial sorting of axons in the sciatic nerve at P5
• arrest in radial sorting, with axon bundles containing naked, mixed caliber axons
abnormal sciatic nerve morphology ( J:204174 )
• arrest in radial sorting, with axon bundles containing mixed caliber axons lacking ensheathing Schwann cells and having redundant and detached basal lamina
abnormal Schwann cell physiology ( J:204174 )
• cells spread less when plated on laminin compared to wild-type cells
abnormal myelination ( J:204174 )
• bundles of naked axons are seen at P15 and P28 in the sciatic nerve




Genotype
MGI:5563093
cn4
Allelic
Composition		 Itga6tm2Egl/Itga6tm2Egl
Tg(Mpz-cre)26Mes/0
Genetic
Background		 involves: C57BL/6 * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga6tm2Egl mutation (0 available); any Itga6 mutation (211 available)
Tg(Mpz-cre)26Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:204174 )
N
• viable

nervous system
decreased myelin sheath thickness ( J:204174 )
• 5% of axons in the sciatic nerve have overly thin myelin for the caliber of the axon
increased myelin sheath thickness ( J:204174 )
• 25% of axons in the sciatic nerve have overly thick myelin for the caliber of the axon
abnormal sciatic nerve morphology ( J:204174 )
• in the sciatic nerve, remak bundles contain axons that are greater than 1 um in diameter suggesting a defect in recognition or sorting of axons
• other large caliber axons in the sciatic nerve are sorted properly but not myelinated suggesting a delay in myelination
• some small caliber axons (less than 1 um in diameter) in the sciatic nerve are abnormally myelinated
• 5% of axons in the sciatic nerve have overly thin myelin for the caliber of the axon
axon degeneration ( J:204174 )
• occasional
abnormal Schwann cell physiology ( J:204174 )
• cells spread less when plated on laminin compared to wild-type cells
abnormal myelination ( J:204174 )
• in the sciatic nerve, remak bundles contain axons that are greater than 1 um in diameter suggesting a defect in recognition or sorting of axons
• other large caliber axons in the sciatic nerve are sorted properly but not myelinated suggesting a delay in myelination
• some small caliber axons (less than 1 um in diameter) in the sciatic nerve are abnormally myelinated
• 5% of axons in the sciatic nerve have overly thin myelin for the caliber of the axon
hypermyelination ( J:204174 )
• 25% of axons in the sciatic nerve have overly thick myelin for the caliber of the axon




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory