All Phenotypes Hs2st1<tm1.1Je> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hs2st1^tm1.1Je
targeted mutation 1.1, Jeffrey D Esko
MGI:4439161

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hs2st1^tm1.1Je/Hs2st1^tm1.1Je Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	B6.Cg-Hs2st1^tm1.1Je Speer6-ps1^{Tg(Alb-cre)21Mgn}	MGI:4439271
cn2	Hs2st1^tm1.1Je/Hs2st1^tm1.1Je Hs6st1^tm1Wvc/Hs6st1^tm1Wvc Hs6st2^tm1Lex/Hs6st2^tm1Lex H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129 * C57BL/6J * CBA/J	MGI:5430387

Allelic Composition	Hs2st1^tm1.1Je/Hs2st1^tm1.1Je Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	B6.Cg-Hs2st1^tm1.1Je Speer6-ps1^{Tg(Alb-cre)21Mgn}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hs2st1^tm1.1Je mutation (2 available); any Hs2st1 mutation (33 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:158299 )

• mice exhibit slower plasma clearance of triglycerides and VLDL compared with wild-type mice

• however, plasma cholesterol levels are normal

increased circulating triglyceride level ( J:158299 )

• 2-fold

liver/biliary system

abnormal hepatocyte physiology ( J:158299 )

• hepatocytes exhibit decreased VLDL binding, uptake, and degradation compared with wild-type cells

Allelic Composition	Hs2st1^tm1.1Je/Hs2st1^tm1.1Je Hs6st1^tm1Wvc/Hs6st1^tm1Wvc Hs6st2^tm1Lex/Hs6st2^tm1Lex H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129 * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Hs2st1^tm1.1Je mutation (2 available); any Hs2st1 mutation (33 available)
Hs6st1^tm1Wvc mutation (3 available); any Hs6st1 mutation (27 available)
Hs6st2^tm1Lex mutation (2 available); any Hs6st2 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:185652 )

N	• lacrimal gland budding is preserved

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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