Phenotypes associated with this allele

• Allele Symbol: Pgr^tm4.2Lyd
• Allele Name: targeted mutation 4.2, John P Lydon
• Allele ID: MGI:4439306
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pgr^tm4.2Lyd/Pgr^tm4.2Lyd	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:4439310

Genotype
MGI:4439310

hm1

• Allelic Composition: Pgr^tm4.2Lyd/Pgr^tm4.2Lyd
• Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Uterine defects in Pgr^tm4.2Lyd/Pgr^tm4.2Lyd and Pgr^tm1Bwo/Pgr^tm1Bwo mice

reproductive system

failure of superovulation ( J:158406 )

♀ • anovulation following gonadotropin hormone treatment

abnormal uterus physiology ( J:158406 )

♀ • hormone-treatment fails to induce a decidual reaction as in similarly treated wild-type mice

♀ • uterus fail to exhibit P4-induced repression of E2-induced luminal epithelial proliferation when exposed to E2P4 unlike wild-type uterus

♀ • P4-directed stromal proliferation is absent unlike in wild-type mice

endocrine/exocrine glands

abnormal mammary gland physiology ( J:158406 )

♀ • E2P4-treatment fails to induce ductal side branching and alveologenesis unlike similarly treated wild-type tissue

♀ • however, ductal elongation and branching during puberty are normal

integument

abnormal mammary gland physiology ( J:158406 )

♀ • E2P4-treatment fails to induce ductal side branching and alveologenesis unlike similarly treated wild-type tissue

♀ • however, ductal elongation and branching during puberty are normal