Phenotypes associated with this allele

• Allele Symbol: Agap2^tm1.1Kye
• Allele Name: targeted mutation 1.1, Keqiang Ye
• Allele ID: MGI:4439325
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agap2^tm1.1Kye/Agap2^tm1.1Kye	involves: C57BL/6	MGI:4439339
hm2	Agap2^tm1.1Kye/Agap2^tm1.1Kye	Not Specified	MGI:5284900

Genotype
MGI:4439339

hm1

• Allelic Composition: Agap2^tm1.1Kye/Agap2^tm1.1Kye
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased mammary gland epithelial cell proliferation ( J:158376 )

♀ • at parturition, mammary epithelial tissue fails to proliferate as in wild-type mice

abnormal mammary gland growth during lactation ( J:158376 )

♀ • postpartum expansion of alveolar buds into mature lobuloalveolar mammary structures is attenuated compared to in wild-type mice

♀ • at parturition, mammary epithelial tissue fails to proliferate as in wild-type mice

abnormal mammary gland alveolus morphology ( J:158376 )

♀ • postpartum alveoli are small and condensed compared to in wild-type mice with closed lumina or accumulated residual luminal secretory lipids

abnormal milk composition ( J:158376 )

♀ • expression of milk proteins at parturition is decreased compared to in wild-type mice

lactation failure ( J:158376 )

♀ • pups of female mice fail to thrive and die within 1 to 2 days of birth with dehydration, low body weight, and empty stomachs indicating a defect in lactation

♀ • however, expression of Tg(MMTV-CCND1)1Esmp rescues lactation defects

increased mammary gland apoptosis ( J:158376 )

♀ • at 13.5 dpc, 18.5 dpc, and postpartum, mammary epithelial cells exhibit increased apoptosis compared to in wild-type mice

cellular

decreased mammary gland epithelial cell proliferation ( J:158376 )

♀ • at parturition, mammary epithelial tissue fails to proliferate as in wild-type mice

integument

decreased mammary gland epithelial cell proliferation ( J:158376 )

♀ • at parturition, mammary epithelial tissue fails to proliferate as in wild-type mice

abnormal mammary gland growth during lactation ( J:158376 )

♀ • postpartum expansion of alveolar buds into mature lobuloalveolar mammary structures is attenuated compared to in wild-type mice

♀ • at parturition, mammary epithelial tissue fails to proliferate as in wild-type mice

abnormal mammary gland alveolus morphology ( J:158376 )

♀ • postpartum alveoli are small and condensed compared to in wild-type mice with closed lumina or accumulated residual luminal secretory lipids

abnormal milk composition ( J:158376 )

♀ • expression of milk proteins at parturition is decreased compared to in wild-type mice

lactation failure ( J:158376 )

♀ • pups of female mice fail to thrive and die within 1 to 2 days of birth with dehydration, low body weight, and empty stomachs indicating a defect in lactation

♀ • however, expression of Tg(MMTV-CCND1)1Esmp rescues lactation defects

increased mammary gland apoptosis ( J:158376 )

♀ • at 13.5 dpc, 18.5 dpc, and postpartum, mammary epithelial cells exhibit increased apoptosis compared to in wild-type mice

Genotype
MGI:5284900

hm2

• Allelic Composition: Agap2^tm1.1Kye/Agap2^tm1.1Kye
• Genetic Background: Not Specified

homeostasis/metabolism

hyperglycemia ( J:174775 )

• in fed and fasted mice

abnormal gluconeogenesis ( J:174775 )

• mice fail to exhibit as great a suppression of hepatic glucose production as in wild-type mice

increased insulin sensitivity ( J:174775 )

• in muscle and fat

insulin resistance ( J:174775 )

• cultured hepatocytes treated with insulin fail to exhibit a decrease in glucose output unlike similarly treated wild-type cells