mortality/aging
• mice die 15 to 60 minutes after birth
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nervous system
• at E13.5, mice exhibit increased proliferation of neurons in superficial layers of the cortical plate compared with wild-type mice indicating defective migration of newer neurons past older neurons
• at E15.5, lower layers of the cortical plate exhibit reduced proliferating cells compared with wild-type mice indicating defective migration into more superficial layers
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• E15.5, neuronal progenitor neurons in the cortex exhibit a modest reduction in proliferation compared to in wild-type mice
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• slightly between E16.5 and E19.5
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• at E16.5, E18.5, and birth, forebrains exhibit defective neuronal layering compared to in wild-type mice with an accumulation of cells in the intermediate zone
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• at E13.5, mice exhibit increased proliferation of neurons in superficial layers of the cortical plate compared with wild-type mice indicating defective migration of newer neurons past older neurons
• at E15.5, lower layers of the cortical plate exhibit reduced proliferating cells compared with wild-type mice indicating defective migration into more superficial layers
• at E18.5, fewer neurons reach the cortical plate compared to in wild-type mice
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• at E19.5 and P0, layers are more compact than in wild-type mice
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• as determined by marker expression
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cellular
• at E13.5, mice exhibit increased proliferation of neurons in superficial layers of the cortical plate compared with wild-type mice indicating defective migration of newer neurons past older neurons
• at E15.5, lower layers of the cortical plate exhibit reduced proliferating cells compared with wild-type mice indicating defective migration into more superficial layers
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• E15.5, neuronal progenitor neurons in the cortex exhibit a modest reduction in proliferation compared to in wild-type mice
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