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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lmnb2tm1Ccof
targeted mutation 1, Catherine Coffinier
MGI:4440427
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lmnb2tm1Ccof/Lmnb2tm1Ccof involves: 129P2/OlaHsd * C57BL/6 MGI:4440435


Genotype
MGI:4440435
hm1
Allelic
Composition
Lmnb2tm1Ccof/Lmnb2tm1Ccof
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnb2tm1Ccof mutation (0 available); any Lmnb2 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die 15 to 60 minutes after birth

nervous system
• at E13.5, mice exhibit increased proliferation of neurons in superficial layers of the cortical plate compared with wild-type mice indicating defective migration of newer neurons past older neurons
• at E15.5, lower layers of the cortical plate exhibit reduced proliferating cells compared with wild-type mice indicating defective migration into more superficial layers
• E15.5, neuronal progenitor neurons in the cortex exhibit a modest reduction in proliferation compared to in wild-type mice
• slightly between E16.5 and E19.5
• at E16.5, E18.5, and birth, forebrains exhibit defective neuronal layering compared to in wild-type mice with an accumulation of cells in the intermediate zone
• at E13.5, mice exhibit increased proliferation of neurons in superficial layers of the cortical plate compared with wild-type mice indicating defective migration of newer neurons past older neurons
• at E15.5, lower layers of the cortical plate exhibit reduced proliferating cells compared with wild-type mice indicating defective migration into more superficial layers
• at E18.5, fewer neurons reach the cortical plate compared to in wild-type mice
• at E19.5 and P0, layers are more compact than in wild-type mice
• as determined by marker expression

cellular
• at E13.5, mice exhibit increased proliferation of neurons in superficial layers of the cortical plate compared with wild-type mice indicating defective migration of newer neurons past older neurons
• at E15.5, lower layers of the cortical plate exhibit reduced proliferating cells compared with wild-type mice indicating defective migration into more superficial layers
• E15.5, neuronal progenitor neurons in the cortex exhibit a modest reduction in proliferation compared to in wild-type mice





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory