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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Doc2btm1Aljg
targeted mutation 1, Alexander J Groffen
MGI:4440451
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Doc2btm1Aljg/Doc2btm1Aljg B6.129P2-Doc2btm1Aljg MGI:4440456
cx2
 		Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Doc2gtm1.2Aljg/Doc2gtm1.2Aljg
Rph3atm1Sud/Rph3atm1Sud
Syt7tm1Sud/Syt7tm1Sud 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:7738542
cx3
 		Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg 		involves: 129P2/OlaHsd * C57BL/6 MGI:4440457
cx4
 		Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Doc2gtm1.2Aljg/Doc2gtm1.2Aljg 		involves: 129P2/OlaHsd * C57BL/6 MGI:7738540
cx5
 		Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Rph3atm1Sud/Rph3atm1Sud 		involves: 129P2/OlaHsd * C57BL/6 MGI:7738541


Genotype
MGI:4440456
hm1
Allelic
Composition		 Doc2btm1Aljg/Doc2btm1Aljg
Genetic
Background		 B6.129P2-Doc2btm1Aljg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Doc2btm1Aljg mutation (0 available); any Doc2b mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal CNS synaptic transmission ( J:158605 )
• Purkinje cells exhibit continuous spiking without interruption unlike wild-type cells
abnormal inhibitory postsynaptic currents ( J:158605 )
• spontaneous inhibitory postsynaptic currents are decreased to one-fourth of wild-type




Genotype
MGI:7738542
cx2
Allelic
Composition		 Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Doc2gtm1.2Aljg/Doc2gtm1.2Aljg
Rph3atm1Sud/Rph3atm1Sud
Syt7tm1Sud/Syt7tm1Sud
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Doc2atm1Ytk mutation (0 available); any Doc2a mutation (15 available)
Doc2btm1Aljg mutation (0 available); any Doc2b mutation (20 available)
Doc2gtm1.2Aljg mutation (0 available); any Doc2g mutation (11 available)
Rph3atm1Sud mutation (1 available); any Rph3a mutation (43 available)
Syt7tm1Sud mutation (1 available); any Syt7 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal synaptic plasticity ( J:317639 )
• short-term plasticity is altered by accentuating short-term depression
abnormal synaptic depression ( J:317639 )
• hippocampal neurons show more pronounced short-term depression
• the deeper short-term depression is not associated with changes in evoked release during burst stimuli
decreased paired-pulse ratio ( J:317639 )
• hippocampal neurons show reduced paired-pulse ratio with a more pronounced short-term depression
• however, spontaneous neurotransmitter release in glutamatergic hippocampal neurons is unaltered




Genotype
MGI:4440457
cx3
Allelic
Composition		 Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Doc2atm1Ytk mutation (0 available); any Doc2a mutation (15 available)
Doc2btm1Aljg mutation (0 available); any Doc2b mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal miniature excitatory postsynaptic currents ( J:158605 )
• mice exhibit decreased spontaneous release frequency of miniature excitatory postsynaptic current (mEPSC) compared with wild-type mice
• however, expression of Doc2b restores normal mEPSC frequency
decreased neurotransmitter release ( J:158605 )
• average spontaneous release frequency is decreased compared to in wild-type mice




Genotype
MGI:7738540
cx4
Allelic
Composition		 Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Doc2gtm1.2Aljg/Doc2gtm1.2Aljg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Doc2atm1Ytk mutation (0 available); any Doc2a mutation (15 available)
Doc2btm1Aljg mutation (0 available); any Doc2b mutation (20 available)
Doc2gtm1.2Aljg mutation (0 available); any Doc2g mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased neurotransmitter release ( J:317639 )
• mice show no additional effect on spontaneous or evoked neurotransmitter release in glutamatergic hippocampal neurons, cultured either in networks or on microglial islands (autapses) compared to that seen in the double Doc2atm1Ytk and Doc2btm1Aljb homozygotes




Genotype
MGI:7738541
cx5
Allelic
Composition		 Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Rph3atm1Sud/Rph3atm1Sud
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Doc2atm1Ytk mutation (0 available); any Doc2a mutation (15 available)
Doc2btm1Aljg mutation (0 available); any Doc2b mutation (20 available)
Rph3atm1Sud mutation (1 available); any Rph3a mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal miniature excitatory postsynaptic currents ( J:317639 )
• miniature excitatory postsynaptic current (mEPSC) release rate of hippocampal neurons in network cultures, but not in autapses, is increased indicating increased spontaneous glutamate release
• the normalized mEPSC frequency is increased and the decay is slightly, but significantly, faster
• however, the amplitude and rise time remains unchanged for hippocampal neurons and the frequency and kinetics of mEPSCs in autaptic neurons are unchanged
increased neurotransmitter release ( J:317639 )
• hippocampal neurons show an increase in spontaneous release frequency in network cultures, but not in autapses




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory