immune system
• lack the normal corticomedullary organization and appear less basophilic
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• 6-8 weeks of age are severely microthymic, 90-fold fewer cells
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• an increase in the percentages of Hardy fraction A-C cells (CD43+), containing the pro-B populations
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• significant accumulation of thymocytes at the DN3 stage reduction of the DN4 population
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• significant accumulation of thymocytes at the DN3 stage reduction of the DN4 population
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• greater than a 10-fold increase in the DN fraction
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• large reduction in the percentages of DP cells
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• in spleen and lymph node
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• a decrease in the percentage of pre-B late cells (Hardy Fraction D, CD43-)
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• decrease in the number of T cells in the peripheral lymph nodes
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• normal red and white pulp architecture is absent
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• weigh about 3 times more than those from wild-type littermates
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• structure of peripheral lymph nodes is abnormal and the number of lymph node T and B cells is decreased
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hematopoietic system
• lack the normal corticomedullary organization and appear less basophilic
|
• 6-8 weeks of age are severely microthymic, 90-fold fewer cells
|
• an increase in the percentages of Hardy fraction A-C cells (CD43+), containing the pro-B populations
|
• significant accumulation of thymocytes at the DN3 stage reduction of the DN4 population
|
• significant accumulation of thymocytes at the DN3 stage reduction of the DN4 population
|
• greater than a 10-fold increase in the DN fraction
|
• in spleen and lymph node
|
• a decrease in the percentage of pre-B late cells (Hardy Fraction D, CD43-)
|
• decrease in the number of T cells in the peripheral lymph nodes
|
• large reduction in the percentages of DP cells
|
• increased number of reticulocytes
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• normal red and white pulp architecture is absent
|
• weigh about 3 times more than those from wild-type littermates
|
endocrine/exocrine glands
• lack the normal corticomedullary organization and appear less basophilic
|
• 6-8 weeks of age are severely microthymic, 90-fold fewer cells
|
growth/size/body
• weigh about 3 times more than those from wild-type littermates
|