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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dcktm1.1Radu
targeted mutation 1.1, Caius G Radu
MGI:4440453
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dcktm1.1Radu/Dcktm1.1Radu involves: 129S4/SvJae * BALB/cJ * C57BL/6 * C57BL/6J MGI:4440454


Genotype
MGI:4440454
hm1
Allelic
Composition
Dcktm1.1Radu/Dcktm1.1Radu
Genetic
Background
involves: 129S4/SvJae * BALB/cJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcktm1.1Radu mutation (0 available); any Dck mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• lack the normal corticomedullary organization and appear less basophilic
• 6-8 weeks of age are severely microthymic, 90-fold fewer cells
• an increase in the percentages of Hardy fraction A-C cells (CD43+), containing the pro-B populations
• significant accumulation of thymocytes at the DN3 stage reduction of the DN4 population
• significant accumulation of thymocytes at the DN3 stage reduction of the DN4 population
• greater than a 10-fold increase in the DN fraction
• large reduction in the percentages of DP cells
• in spleen and lymph node
• a decrease in the percentage of pre-B late cells (Hardy Fraction D, CD43-)
• decrease in the number of T cells in the peripheral lymph nodes
• normal red and white pulp architecture is absent
• weigh about 3 times more than those from wild-type littermates
• structure of peripheral lymph nodes is abnormal and the number of lymph node T and B cells is decreased

hematopoietic system
• lack the normal corticomedullary organization and appear less basophilic
• 6-8 weeks of age are severely microthymic, 90-fold fewer cells
• an increase in the percentages of Hardy fraction A-C cells (CD43+), containing the pro-B populations
• significant accumulation of thymocytes at the DN3 stage reduction of the DN4 population
• significant accumulation of thymocytes at the DN3 stage reduction of the DN4 population
• greater than a 10-fold increase in the DN fraction
• in spleen and lymph node
• a decrease in the percentage of pre-B late cells (Hardy Fraction D, CD43-)
• decrease in the number of T cells in the peripheral lymph nodes
• large reduction in the percentages of DP cells
• increased number of reticulocytes
• normal red and white pulp architecture is absent
• weigh about 3 times more than those from wild-type littermates

endocrine/exocrine glands
• lack the normal corticomedullary organization and appear less basophilic
• 6-8 weeks of age are severely microthymic, 90-fold fewer cells

growth/size/body
• weigh about 3 times more than those from wild-type littermates





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory