All Phenotypes Ret<tm1.2Pern> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ret^tm1.2Pern
targeted mutation 1.2, Patrik Ernfors
MGI:4440476

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ret^tm1.2Pern/Ret^tm1.2Pern	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL	MGI:4440539

Allelic Composition	Ret^tm1.2Pern/Ret^tm1.2Pern
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1.2Pern mutation (0 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:131770 )

• animals die at birth

renal/urinary system

abnormal kidney development ( J:131770 )

• kidney development fails

nervous system

abnormal neuromuscular synapse morphology ( J:131770 )

• synapse development is abnormal; postsynaptic acetylcholine receptor (AChR) clustering is reduced and shows a lack of streaks of more intense specializations at neuromuscular synapses in the tongue compared to wild-type

• nerve terminal sprouting from intact terminals is often observed in contrast to control mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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