Analysis Tools
skeleton
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• in one mouse
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mortality/aging
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• despite normal atherogenic lesions and lipid serum levels, mice fed a high-fat, high-cholesterol diet exhibit increased mortality compared with similarly treated wild-type mice
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• mice are less likely than wild-type mice to survive up to 55 weeks
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• mortality between birth and weaning is increased compared to in wild-type mice
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• fewer than expected mice are present from E11.5 to E16.5
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neoplasm
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• 9 of 20 mice develop internal neoplasms or tumors unlike wild-type mice
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• some mice develop sarcomas including hemangiosarcoma and osteosarcoma unlike wild-type mice
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• in some mice
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• in one mouse
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• in one mouse
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cardiovascular system
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• aortic smooth muscle cells exhibit delayed senescence in culture compared with wild-type cells
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• aortic smooth muscle cells a 2-fold increase in proliferation compared with wild-type cells
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cellular
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• aortic smooth muscle cells a 2-fold increase in proliferation compared with wild-type cells
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• embryonic fibroblasts exhibit a 3-fold increase in proliferation compared with wild-type cells
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• aortic smooth muscle cells and embryonic fibroblasts exhibit delayed senescence compared with wild-type cells
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growth/size/body
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• when fed a standard diet, body weight is increase 17% by 30 weeks compared with wild-type mice
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reproductive system
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• one mouse develops metritis unlike wild-type mice
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immune system
liver/biliary system
homeostasis/metabolism
| N |
• mice exhibit normal atherogenic lesions and lipid serum levels in response to a high-fat, high-cholesterol diet
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hematopoietic system
muscle
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• aortic smooth muscle cells exhibit delayed senescence in culture compared with wild-type cells
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• aortic smooth muscle cells a 2-fold increase in proliferation compared with wild-type cells
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