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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hdac1tm1.1Pmt
targeted mutation 1.1, Patrick Matthias
MGI:4440556
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hdac1tm1.1Pmt/Hdac1tm1.1Pmt involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4440608
cn2
 		Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Cd79atm1(cre)Reth/Cd79a+ 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N MGI:4440609
cn3
 		Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Tg(Fcer2a-cre)5Mbu/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N MGI:4440610
cn4
 		Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4440612


Genotype
MGI:4440608
cn1
Allelic
Composition		 Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1tm1.1Pmt mutation (0 available); any Hdac1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cell proliferation ( J:157903 )
• MEFs with inducible Cre show a slow proliferation phenotype




Genotype
MGI:4440609
cn2
Allelic
Composition		 Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Hdac1tm1.1Pmt mutation (0 available); any Hdac1 mutation (38 available)
Hdac2tm1.1Pmt mutation (0 available); any Hdac2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B cell apoptosis ( J:157903 )
• of pre BII cells and large pre BII cells
decreased pro-B cell number ( J:157903 )
• numbers of pre BI cells are reduced by 60%-80%
arrested B cell differentiation ( J:157903 )
• block in B cell differentiation as early as the pre BI cell stage only 4.5% of pre B cells are in S phase compared to 80% for wild-type cells
decreased bone marrow cell number ( J:157903 )
• only a very few B cells remain
decreased B cell number ( J:157903 )
• spleen is virtually empty of circulating mature B cells
• in bone marrow, only a very few B cells remain
decreased pre-B cell number ( J:157903 )
• fewer than 1% of pre BII cell stage cells remain
abnormal spleen morphology ( J:157903 )
• virtually empty of circulating mature B cells

immune system
increased B cell apoptosis ( J:157903 )
• of pre BII cells and large pre BII cells
decreased pro-B cell number ( J:157903 )
• numbers of pre BI cells are reduced by 60%-80%
arrested B cell differentiation ( J:157903 )
• block in B cell differentiation as early as the pre BI cell stage only 4.5% of pre B cells are in S phase compared to 80% for wild-type cells
decreased B cell number ( J:157903 )
• spleen is virtually empty of circulating mature B cells
• in bone marrow, only a very few B cells remain
decreased pre-B cell number ( J:157903 )
• fewer than 1% of pre BII cell stage cells remain
abnormal spleen morphology ( J:157903 )
• virtually empty of circulating mature B cells

cellular
increased B cell apoptosis ( J:157903 )
• of pre BII cells and large pre BII cells




Genotype
MGI:4440610
cn3
Allelic
Composition		 Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Tg(Fcer2a-cre)5Mbu/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1tm1.1Pmt mutation (0 available); any Hdac1 mutation (38 available)
Hdac2tm1.1Pmt mutation (0 available); any Hdac2 mutation (40 available)
Tg(Fcer2a-cre)5Mbu mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell apoptosis ( J:157903 )
• massive induction of apoptosis is detected when cells are cultured with LPS and IL4 or anti-IgM Fab
decreased B cell proliferation ( J:157903 )
• fail to proliferate in response to LPS and IL4 or anti-IgM Fab fragment stimulation

hematopoietic system
increased B cell apoptosis ( J:157903 )
• massive induction of apoptosis is detected when cells are cultured with LPS and IL4 or anti-IgM Fab
decreased B cell proliferation ( J:157903 )
• fail to proliferate in response to LPS and IL4 or anti-IgM Fab fragment stimulation

cellular
increased B cell apoptosis ( J:157903 )
• massive induction of apoptosis is detected when cells are cultured with LPS and IL4 or anti-IgM Fab
decreased B cell proliferation ( J:157903 )
• fail to proliferate in response to LPS and IL4 or anti-IgM Fab fragment stimulation




Genotype
MGI:4440612
cn4
Allelic
Composition		 Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1tm1.1Pmt mutation (0 available); any Hdac1 mutation (38 available)
Hdac2tm1.1Pmt mutation (0 available); any Hdac2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:157903 )
• Cre mediated recombination results in G1 arrest in MEFs
increased fibroblast apoptosis ( J:157903 )
• arrested Cre recombined MEFs die by apoptosis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory