About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hdac2tm1.1Pmt
targeted mutation 1.1, Patrick Matthias
MGI:4440560
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Cd79atm1(cre)Reth/Cd79a+ 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N MGI:4440609
cn2
 		Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Tg(Fcer2a-cre)5Mbu/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N MGI:4440610
cn3
 		Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4440612


Genotype
MGI:4440609
cn1
Allelic
Composition		 Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Hdac1tm1.1Pmt mutation (0 available); any Hdac1 mutation (38 available)
Hdac2tm1.1Pmt mutation (0 available); any Hdac2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B cell apoptosis ( J:157903 )
• of pre BII cells and large pre BII cells
decreased pro-B cell number ( J:157903 )
• numbers of pre BI cells are reduced by 60%-80%
arrested B cell differentiation ( J:157903 )
• block in B cell differentiation as early as the pre BI cell stage only 4.5% of pre B cells are in S phase compared to 80% for wild-type cells
decreased bone marrow cell number ( J:157903 )
• only a very few B cells remain
decreased B cell number ( J:157903 )
• spleen is virtually empty of circulating mature B cells
• in bone marrow, only a very few B cells remain
decreased pre-B cell number ( J:157903 )
• fewer than 1% of pre BII cell stage cells remain
abnormal spleen morphology ( J:157903 )
• virtually empty of circulating mature B cells

immune system
increased B cell apoptosis ( J:157903 )
• of pre BII cells and large pre BII cells
decreased pro-B cell number ( J:157903 )
• numbers of pre BI cells are reduced by 60%-80%
arrested B cell differentiation ( J:157903 )
• block in B cell differentiation as early as the pre BI cell stage only 4.5% of pre B cells are in S phase compared to 80% for wild-type cells
decreased B cell number ( J:157903 )
• spleen is virtually empty of circulating mature B cells
• in bone marrow, only a very few B cells remain
decreased pre-B cell number ( J:157903 )
• fewer than 1% of pre BII cell stage cells remain
abnormal spleen morphology ( J:157903 )
• virtually empty of circulating mature B cells

cellular
increased B cell apoptosis ( J:157903 )
• of pre BII cells and large pre BII cells




Genotype
MGI:4440610
cn2
Allelic
Composition		 Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Tg(Fcer2a-cre)5Mbu/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1tm1.1Pmt mutation (0 available); any Hdac1 mutation (38 available)
Hdac2tm1.1Pmt mutation (0 available); any Hdac2 mutation (40 available)
Tg(Fcer2a-cre)5Mbu mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell apoptosis ( J:157903 )
• massive induction of apoptosis is detected when cells are cultured with LPS and IL4 or anti-IgM Fab
decreased B cell proliferation ( J:157903 )
• fail to proliferate in response to LPS and IL4 or anti-IgM Fab fragment stimulation

hematopoietic system
increased B cell apoptosis ( J:157903 )
• massive induction of apoptosis is detected when cells are cultured with LPS and IL4 or anti-IgM Fab
decreased B cell proliferation ( J:157903 )
• fail to proliferate in response to LPS and IL4 or anti-IgM Fab fragment stimulation

cellular
increased B cell apoptosis ( J:157903 )
• massive induction of apoptosis is detected when cells are cultured with LPS and IL4 or anti-IgM Fab
decreased B cell proliferation ( J:157903 )
• fail to proliferate in response to LPS and IL4 or anti-IgM Fab fragment stimulation




Genotype
MGI:4440612
cn3
Allelic
Composition		 Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1tm1.1Pmt mutation (0 available); any Hdac1 mutation (38 available)
Hdac2tm1.1Pmt mutation (0 available); any Hdac2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:157903 )
• Cre mediated recombination results in G1 arrest in MEFs
increased fibroblast apoptosis ( J:157903 )
• arrested Cre recombined MEFs die by apoptosis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory