mortality/aging
• unlike wild-type mice that die from fatal hepatitis within 3?4 hr of anti-Fas antibody treatment, all mutants survive
• homozygous mice develop and age normally and have no increased incidence of tumor development
• cell subset composition and total cellularity of thymus, spleen, and lymph nodes were normal
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homeostasis/metabolism
• animals survive with little or no liver damage and normal serum levels of ALT and AST and normal liver architecture after injection with anti-Fas antibodies
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cellular
N |
• unlike other reports, hematopoietic cell and fibroblasts from homozygous mice are normally sensitive to apoptotic stimuli including DNA damage and gamma-irradiation or treatment with etoposide
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