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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bidtm1.1Ast
targeted mutation 1.1, Andreas Strasser
MGI:4440571
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Bidtm1.1Ast/Bidtm1.1Ast involves: BALB/cJ * C57BL/6 * NZB MGI:4440572


Genotype
MGI:4440572
hm1
Allelic
Composition
Bidtm1.1Ast/Bidtm1.1Ast
Genetic
Background
involves: BALB/cJ * C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bidtm1.1Ast mutation (1 available); any Bid mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• unlike wild-type mice that die from fatal hepatitis within 3?4 hr of anti-Fas antibody treatment, all mutants survive
• homozygous mice develop and age normally and have no increased incidence of tumor development
• cell subset composition and total cellularity of thymus, spleen, and lymph nodes were normal

homeostasis/metabolism
• animals survive with little or no liver damage and normal serum levels of ALT and AST and normal liver architecture after injection with anti-Fas antibodies

cellular
N
• unlike other reports, hematopoietic cell and fibroblasts from homozygous mice are normally sensitive to apoptotic stimuli including DNA damage and gamma-irradiation or treatment with etoposide





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory