Phenotypes associated with this allele

• Allele Symbol: Ccn3^tm1.1Ecan
• Allele Name: targeted mutation 1.1, Ernesto Canalis
• Allele ID: MGI:4440613
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccn3^tm1.1Ecan/Ccn3^tm1.1Ecan	B6.Cg-Ccn3^tm1.1Ecan	MGI:4440615

Genotype
MGI:4440615

hm1

• Allelic Composition: Ccn3^tm1.1Ecan/Ccn3^tm1.1Ecan
• Genetic Background: B6.Cg-Ccn3^tm1.1Ecan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:158478 )

N • mice exhibit normal skeletal structure

abnormal skeleton morphology ( J:158478 )

abnormal osteoclast differentiation ( J:158478 )

• cultured bone marrow stromal cells exhibit increased differentiation into osteoclasts compared with wild-type bone marrow stroma cells

long femur ( J:158478 )

• in female mice at 7 months

decreased bone volume ( J:158478 )

• at 1 month, female mice exhibit a modest decrease in bone volume to tissue volume compared with wild-type mice

increased compact bone thickness ( J:158478 )

• in female mice at 1 month and 10 months

decreased bone trabecula number ( J:158478 )

• at 1 month, female mice exhibit decreased number of trabeculae compared with wild-type mice

abnormal skeleton physiology ( J:158478 )

abnormal osteoblast physiology ( J:158478 )

• 10 month old female mice exhibit increased osteoblast surface to bone surface and mineralization surface compared with wild-type mice

abnormal osteoclast physiology ( J:158478 )

• 7 month old mice exhibit increased osteoclast to perimeter and eroded surface compared with wild-type mice

abnormal bone ossification ( J:158478 )

• 10 month old female mice exhibit increased osteoblast surface to bone surface, mineralization surface, and bone formation compared with wild-type mice

• however, male mice exhibit normal bone ossification

adipose tissue

adipose tissue phenotype ( J:158478 )

N • mice exhibit normal body fat

limbs/digits/tail

long femur ( J:158478 )

• in female mice at 7 months

growth/size/body

growth/size/body region phenotype ( J:158478 )

N • mice exhibit normal body weight

hematopoietic system

abnormal osteoclast differentiation ( J:158478 )

• cultured bone marrow stromal cells exhibit increased differentiation into osteoclasts compared with wild-type bone marrow stroma cells

abnormal osteoclast physiology ( J:158478 )

• 7 month old mice exhibit increased osteoclast to perimeter and eroded surface compared with wild-type mice

immune system

abnormal osteoclast differentiation ( J:158478 )

• cultured bone marrow stromal cells exhibit increased differentiation into osteoclasts compared with wild-type bone marrow stroma cells

abnormal osteoclast physiology ( J:158478 )

• 7 month old mice exhibit increased osteoclast to perimeter and eroded surface compared with wild-type mice

cellular

abnormal osteoclast differentiation ( J:158478 )

• cultured bone marrow stromal cells exhibit increased differentiation into osteoclasts compared with wild-type bone marrow stroma cells

abnormal osteoblast physiology ( J:158478 )

• 10 month old female mice exhibit increased osteoblast surface to bone surface and mineralization surface compared with wild-type mice