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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sec24bY613X
Tyr613Stop
MGI:4440619
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sec24bY613X/Sec24bY613X involves: C3H/He * C57BL/6 MGI:4440637
cx2
 		Sec24bY613X/Sec24b+
Vangl2Lp/Vangl2+ 		involves: A * C3H/He * C57BL/6 MGI:4440638


Genotype
MGI:4440637
hm1
Allelic
Composition		 Sec24bY613X/Sec24bY613X
Genetic
Background		 involves: C3H/He * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec24bY613X mutation (1 available); any Sec24b mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
abnormal orientation of inner hair cell stereociliary bundles ( J:158452 )
• across entire organ of Corti but not in the vestibular system
abnormal orientation of outer hair cell stereociliary bundles ( J:158452 )
• across entire organ of Corti but not in the vestibular system

embryo
abnormal embryo size ( J:158452 )
• at the 6-, 7-, 8-, and 10-somite stages, embryos are shorter and wider than wild-type mice

growth/size/body
abnormal embryo size ( J:158452 )
• at the 6-, 7-, 8-, and 10-somite stages, embryos are shorter and wider than wild-type mice
omphalocele ( J:158452 )
• in 45% of mice at E18.5 compared with 1% of mice

vision/eye
failure of eyelid fusion ( J:158452 )
• in 99% of mice at E18.5 compared with 2% of mice

hearing/vestibular/ear
abnormal orientation of inner hair cell stereociliary bundles ( J:158452 )
• across entire organ of Corti but not in the vestibular system
abnormal orientation of outer hair cell stereociliary bundles ( J:158452 )
• across entire organ of Corti but not in the vestibular system




Genotype
MGI:4440638
cx2
Allelic
Composition		 Sec24bY613X/Sec24b+
Vangl2Lp/Vangl2+
Genetic
Background		 involves: A * C3H/He * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec24bY613X mutation (1 available); any Sec24b mutation (68 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:158452 )
• over 50% of mice die between late embryogenesis and four weeks of age
postnatal lethality, incomplete penetrance ( J:158452 )
• over 50% of mice die between late embryogenesis and four weeks of age

nervous system
spina bifida ( J:158452 )
• in 68% of mice

embryo
spina bifida ( J:158452 )
• in 68% of mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory