Analysis Tools|
Allele Symbol Allele Name Allele ID |
Sec24bkrb krabbel MGI:4440621 |
| Summary |
3 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Lung development is affected in Sec24bkrb/Sec24bkrb embryos
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• lethality is observed by E17.5
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• at E16.5, the cochlea is smaller than in wild-type mice
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• the organ of Corti is decreased in length compared to in wild-type mice
• at E17.5, the organ of Corti is disorganized unlike in wild-type mice
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• mice exhibit out of line and misoriented inner hair cells in the organ of Corti unlike wild-type mice
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• mice exhibit supernumerary rows of outer hair cells unlike wild-type mice
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• severe in 95% of mice with remaining mice exhibiting a weaker phenotype
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• mice exhibit out of line and misoriented inner hair cells in the organ of Corti unlike wild-type mice
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• mice exhibit supernumerary rows of outer hair cells unlike wild-type mice
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• at E15.5
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• at E16.5, mice exhibit abnormal orientation of the great outflow vessels unlike wild-type mice
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• at E15.5, mice exhibit an aberrant, rightward directed pulmonary artery unlike wild-type mice
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• at E16.5
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• severe in 95% of mice with remaining mice exhibiting a weaker phenotype
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• at E17.5, yolk sacs are filled with blood and local effusion unlike in wild-type mice
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• in less than 5% of mice
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• irregularly shaped at E17.5
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• at E17.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the organ of Corti is decreased in length compared to in wild-type mice
• at E17.5, the organ of Corti is disorganized unlike in wild-type mice
|
|
• mice exhibit out of line and misoriented inner hair cells in the organ of Corti unlike wild-type mice
• mice exhibit a more severe phenotype compared with Sec24bkrb homozygotes
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• mice exhibit supernumerary rows of outer hair cells unlike wild-type mice
|
|
• mice exhibit out of line and misoriented inner hair cells in the organ of Corti unlike wild-type mice
• mice exhibit a more severe phenotype compared with Sec24bkrb homozygotes
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• mice exhibit supernumerary rows of outer hair cells unlike wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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