All Phenotypes Sec24b<krb> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sec24b^krb/Sec24b^krb	involves: C57BL/6	MGI:4440639
hm2	Sec24b^krb/Sec24b^krb	involves: C57BL/6 * FVB/N	MGI:4440751
cx3	Scrib^m51206BHubr/Scrib⁺ Sec24b^krb/Sec24b^krb	involves: C57BL/6 * FVB/N	MGI:4440753

Allelic Composition	Sec24b^krb/Sec24b^krb
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec24b^krb mutation (0 available); any Sec24b mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

craniorachischisis ( J:158452 )

nervous system

craniorachischisis ( J:158452 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Lung development is affected in Sec24b^krb/Sec24b^krb embryos

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:158680 )

• lethality is observed by E17.5

hearing/vestibular/ear

abnormal cochlea morphology ( J:158680 )

• at E16.5, the cochlea is smaller than in wild-type mice

abnormal organ of Corti morphology ( J:158680 )

• the organ of Corti is decreased in length compared to in wild-type mice

• at E17.5, the organ of Corti is disorganized unlike in wild-type mice

abnormal cochlear inner hair cell morphology ( J:158680 )

• mice exhibit out of line and misoriented inner hair cells in the organ of Corti unlike wild-type mice

abnormal cochlear outer hair cell morphology ( J:158680 )

• mice exhibit supernumerary rows of outer hair cells unlike wild-type mice

abnormal orientation of outer hair cell stereociliary bundles ( J:158680 )

nervous system

abnormal neural tube closure ( J:158680 )

• severe in 95% of mice with remaining mice exhibiting a weaker phenotype

craniorachischisis ( J:158680 , J:173681 )

abnormal cochlear inner hair cell morphology ( J:158680 )

• mice exhibit out of line and misoriented inner hair cells in the organ of Corti unlike wild-type mice

abnormal cochlear outer hair cell morphology ( J:158680 )

• mice exhibit supernumerary rows of outer hair cells unlike wild-type mice

abnormal orientation of outer hair cell stereociliary bundles ( J:158680 )

cardiovascular system

retroesophageal right subclavian artery ( J:158680 )

• at E15.5

abnormal cardiac outflow tract development ( J:158680 )

• at E16.5, mice exhibit abnormal orientation of the great outflow vessels unlike wild-type mice

transposition of great arteries ( J:158680 )

• at E15.5, mice exhibit an aberrant, rightward directed pulmonary artery unlike wild-type mice

ventricular hypoplasia ( J:158680 )

• at E16.5

embryo

abnormal neural tube closure ( J:158680 )

• severe in 95% of mice with remaining mice exhibiting a weaker phenotype

craniorachischisis ( J:158680 , J:173681 )

abnormal visceral yolk sac morphology ( J:158680 )

• at E17.5, yolk sacs are filled with blood and local effusion unlike in wild-type mice

growth/size/body

herniated abdominal wall ( J:158680 )

• in less than 5% of mice

respiratory system

abnormal lung lobe morphology ( J:173681 )

• irregularly shaped at E17.5

small lung ( J:173681 )

• at E17.5

Allelic Composition	Scrib^m51206BHubr/Scrib⁺ Sec24b^krb/Sec24b^krb
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scrib^m51206BHubr mutation (0 available); any Scrib mutation (54 available)
Sec24b^krb mutation (0 available); any Sec24b mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal organ of Corti morphology ( J:158680 )

• the organ of Corti is decreased in length compared to in wild-type mice

• at E17.5, the organ of Corti is disorganized unlike in wild-type mice

abnormal cochlear inner hair cell morphology ( J:158680 )

• mice exhibit out of line and misoriented inner hair cells in the organ of Corti unlike wild-type mice

• mice exhibit a more severe phenotype compared with Sec24b^krb homozygotes

abnormal cochlear outer hair cell morphology ( J:158680 )

• mice exhibit supernumerary rows of outer hair cells unlike wild-type mice

abnormal orientation of outer hair cell stereociliary bundles ( J:158680 )

nervous system

abnormal cochlear inner hair cell morphology ( J:158680 )

• mice exhibit out of line and misoriented inner hair cells in the organ of Corti unlike wild-type mice

• mice exhibit a more severe phenotype compared with Sec24b^krb homozygotes

abnormal cochlear outer hair cell morphology ( J:158680 )

• mice exhibit supernumerary rows of outer hair cells unlike wild-type mice

abnormal orientation of outer hair cell stereociliary bundles ( J:158680 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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