All Phenotypes Scrib<m51206BHubr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Scrib^m51206BHubr
mutation 51206B, Hubrecht Institute
MGI:4440642

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scrib^m51206BHubr/Scrib^m51206BHubr	involves: C57BL/6 * FVB/N	MGI:4440752
cx2	Scrib^m51206BHubr/Scrib⁺ Sec24b^krb/Sec24b^krb	involves: C57BL/6 * FVB/N	MGI:4440753

Allelic Composition	Scrib^m51206BHubr/Scrib^m51206BHubr
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scrib^m51206BHubr mutation (0 available); any Scrib mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Lung development is affected in Scrib^m51206BHubr/Scrib^m51206BHubr embryos

hearing/vestibular/ear

abnormal organ of Corti morphology ( J:158680 )

• the organ of Corti is decreased in length compared to in wild-type mice

• at E17.5, the organ of Corti is disorganized unlike in wild-type mice

abnormal cochlear inner hair cell morphology ( J:158680 )

• mice exhibit out of line and misoriented inner hair cells in the organ of Corti unlike wild-type mice

nervous system

craniorachischisis ( J:158680 , J:173681 )

abnormal cochlear inner hair cell morphology ( J:158680 )

• mice exhibit out of line and misoriented inner hair cells in the organ of Corti unlike wild-type mice

respiratory system

abnormal lung lobe morphology ( J:173681 )

• irregularly shaped at E17.5

small lung ( J:173681 )

• at E17.5

growth/size/body

herniated abdominal wall ( J:158680 )

• in about half of mice

embryo

craniorachischisis ( J:158680 , J:173681 )

Allelic Composition	Scrib^m51206BHubr/Scrib⁺ Sec24b^krb/Sec24b^krb
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scrib^m51206BHubr mutation (0 available); any Scrib mutation (54 available)
Sec24b^krb mutation (0 available); any Sec24b mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal organ of Corti morphology ( J:158680 )

• the organ of Corti is decreased in length compared to in wild-type mice

• at E17.5, the organ of Corti is disorganized unlike in wild-type mice

abnormal cochlear inner hair cell morphology ( J:158680 )

• mice exhibit out of line and misoriented inner hair cells in the organ of Corti unlike wild-type mice

• mice exhibit a more severe phenotype compared with Sec24b^krb homozygotes

abnormal cochlear outer hair cell morphology ( J:158680 )

• mice exhibit supernumerary rows of outer hair cells unlike wild-type mice

abnormal orientation of outer hair cell stereociliary bundles ( J:158680 )

nervous system

abnormal cochlear inner hair cell morphology ( J:158680 )

• mice exhibit out of line and misoriented inner hair cells in the organ of Corti unlike wild-type mice

• mice exhibit a more severe phenotype compared with Sec24b^krb homozygotes

abnormal cochlear outer hair cell morphology ( J:158680 )

• mice exhibit supernumerary rows of outer hair cells unlike wild-type mice

abnormal orientation of outer hair cell stereociliary bundles ( J:158680 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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