All Phenotypes Tg(SFTPC-cre)#Mliu MGI Mouse

abnormal induced morbidity/mortality ( J:158566 )

• after intestinal ischemia/reperfusion (IIR) injury in 7- to 10-week old animals, mortality at 24 hours is 15% compared to 25% in wild-type controls

respiratory system phenotype ( J:158566 )

N	• 7-10 week-old mutants show normal lung morphology; blood gas analyses and bronchoalveolar lavage for total and differential cell counts are not different from controls

abnormal lung morphology ( J:158566 )

• acute lung injury (ALI) is ameliorated in 7- to 10-week-old mutants after IIR

• fibrin deposition is rare along alveolar septa and absent within alveolar spaces after IIR in contrast to wild-type at 7 to 10 weeks where dense deposits of fibrin are detected in small vessels and along alveolar septa

pulmonary edema ( J:158566 )

• interstitial edema is lower in mutants after IIR compared to controls at 7 to 10 weeks

abnormal respiratory system physiology ( J:158566 )

• during acute lung injury effected by IIR in 7- to 10-week old animals, epithelial cell death via caspase-dependent mechanisms is significantly higher in mutants than in wild-type controls

abnormal pulmonary circulation ( J:158566 )

• pulmonary vascular permeability is significantly lower than in wild-type controls at 7 to 10 weeks of age

lung inflammation ( J:158566 )

• following IIR in 7- to 10-week old animals, inflammatory mononuclear cell infiltration is significantly reduced compare to wild-type controls

emphysema ( J:158566 )

• emphysema is detected in animals at 28- to 32-weeks of age; significant airspace enlargement is seen histologically and increased lung volume is observed in some cases compared to wild-type mice

abnormal lung compliance ( J:158566 )