All Phenotypes Bhlhe22<tm1Meg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bhlhe22^tm1Meg
targeted mutation 1, Michael E Greenberg
MGI:4440742

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bhlhe22^tm1Meg/Bhlhe22^tm1Meg	either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)	MGI:4440897
hm2	Bhlhe22^tm1Meg/Bhlhe22^tm1Meg	involves: 129S6/SvEvTac * C57BL/6J	MGI:5315765
cn3	Bhlhe22^{tm3.1(cre)Meg}/Bhlhe22^tm1Meg Tg(CAG-Bgeo/GFP)21Lbe/0	involves: 129S1/Sv * 129X1/SvJ	MGI:4440936
cn4	Bhlhe22^{tm3.1(cre)Meg}/Bhlhe22^tm1Meg Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺	involves: 129/Sv * 129S4/SvJaeSor	MGI:4440937
cn5	Bhlhe22^{tm3.1(cre)Meg}/Bhlhe22^tm1Meg Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺	involves: 129/Sv * 129X1/SvJ	MGI:4440935
cx6	Bhlhe22^tm1Meg/Bhlhe22^tm1Meg Cdh11^tm1Mta/Cdh11^tm1Mta	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J	MGI:5315766

Allelic Composition	Bhlhe22^tm1Meg/Bhlhe22^tm1Meg
Genetic Background	either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22^tm1Meg mutation (0 available); any Bhlhe22 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:158273 )

• excessive licking along with scratching results in skin lesions in most animals

excessive scratching ( J:158273 )

• resulting in skin lesions in most animals

abnormal sensory capabilities/reflexes/nociception ( J:158273 )

• mice show significantly greated scratching behavior than wild-type in response to all pruritic agents

abnormal chemical nociception ( J:158273 )

• in response to intraplantar formalin injection, the initial early phase reaction is similar to controls, but the late phase response is significantly enhanced with the duration of licking behavior is 4 fold greater in mutants; intradermal injection in the cheek induces a scratching (itching sensation) response rather than a wiping response (pain sensation)

• mice show similar responses to nociceptive sensory assays (mechanical sensitivity, thermal sensitivity, inflammation-induced mechanical hypersensitivity) as wild-type animals at 4 weeks of age

nervous system

abnormal nervous system physiology ( J:158273 )

• elevated neural activity associated with the presence of skin lesions is observed in the dorsal horn of the spinal cord; c-Fos activity is upregulated

• no neuropathy or abnormal innervation of the skin is observed

integument

skin lesions ( J:158273 )

• by 4 weeks of age, one third of animals display self-inflicted skin lesions frequently observed on the perineum and haunches; at 8 weeks, almost all animals have lesions

Allelic Composition	Bhlhe22^tm1Meg/Bhlhe22^tm1Meg
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22^tm1Meg mutation (0 available); any Bhlhe22 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:182304 )

N	• mice exhibit normal cortical layering

abnormal axon guidance ( J:182304 )

• axons from corticospinal motor neurons terminal prematurely and fail to enter the spinal cord unlike in wild-type mice

absent corpus callosum ( J:182304 )

absent hippocampal commissure ( J:182304 )

absent anterior commissure ( J:182304 )

abnormal anterior corticospinal tract morphology ( J:182304 )

• mice exhibit a reduction of the corticospinal tract compared with wild-type mice

behavior/neurological

excessive scratching ( J:182304 )

• resulting in skin lesions at 6 weeks of age

abnormal motor coordination/balance ( J:182304 )

• a few mice exhibit a handstand phenotype (walking on forepaws) secondary to hindpaw contraction

integument

skin lesions ( J:182304 )

• due to excessive scratching at 6 weeks of age

cellular

abnormal axon guidance ( J:182304 )

• axons from corticospinal motor neurons terminal prematurely and fail to enter the spinal cord unlike in wild-type mice

Allelic Composition	Bhlhe22^{tm3.1(cre)Meg}/Bhlhe22^tm1Meg Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22^tm1Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Bhlhe22^{tm3.1(cre)Meg} mutation (0 available); any Bhlhe22 mutation (12 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased neuron number ( J:158273 )

abnormal spinal cord dorsal horn morphology ( J:158273 )

• in the superficial laminae of spinal cord, there are significantly fewer lacZ-marked neurons compared to controls; significant loss of cell bodies and neuropil is observed

Allelic Composition	Bhlhe22^{tm3.1(cre)Meg}/Bhlhe22^tm1Meg Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129/Sv * 129S4/SvJaeSor

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased neuron number ( J:158273 )

abnormal spinal cord dorsal horn morphology ( J:158273 )

• in the superficial dorsal horn, there are significantly fewer ( about 50%) lacZ-marked neurons compared to controls

Allelic Composition	Bhlhe22^{tm3.1(cre)Meg}/Bhlhe22^tm1Meg Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal spinal cord dorsal horn morphology ( J:158273 )

• quantification of neurons at P0 shows a 50% decrease in number of marked neurons in superficial dorsal horn compared to controls with no difference in numbers in any other spinal cord region

• significant increase in number of apoptotic cells (marked neurons) in superficial dorsal horn is observed at E18.5, but no difference is observed at E17.5 or 19.5

• partial loss of glutamatergic and GABAergic neurons is observed in dorsal horn

• number of marked neurons in dorsal horn are not different from controls when BrdU labeling is done at E12.5 or E13.5 and analysis is done at E17.5, indicating that neuronal mitosis is not affected

Allelic Composition	Bhlhe22^tm1Meg/Bhlhe22^tm1Meg Cdh11^tm1Mta/Cdh11^tm1Mta
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22^tm1Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Cdh11^tm1Mta mutation (1 available); any Cdh11 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

skin lesions ( J:182304 )

• at 13 weeks, delayed compared to in Bhlhe22^tm1Meg homozygotes

nervous system

abnormal anterior corticospinal tract morphology ( J:182304 )

• mice exhibit a reduction of the corticospinal tract compared with wild-type mice although not as severe as in Bhlhe22^tm1Meg homozygotes

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