mortality/aging
• 100% lethality by E12.5
|
embryo
• increased apoptosis in cephalic mesoderm at E9.5
|
• developmental arrest after gastrulation
|
• by E9.5
|
• failure of outgrowth of allantois
|
cellular
• global CpG methylation is substantially reduced
|
nervous system
• increased apoptosis in the ventral region of the neurtaql tubre at E9.5
|
craniofacial
skeleton
• increased apoptosis at E9.5
|
growth/size/body
• by E9.5
|