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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rab25tm1Jrgo
targeted mutation 1, James R Goldenring
MGI:4440861
Summary 4 genotypes


Genotype
MGI:4440862
hm1
Allelic
Composition		 Rab25tm1Jrgo/Rab25tm1Jrgo
Genetic
Background		 129-Rab25tm1Jrgo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab25tm1Jrgo mutation (1 available); any Rab25 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal vagina epithelium morphology ( J:158733 )
• vaginal cancer in virgin females after 10 months of age
• neoplastic vaginal squamous epithelial cells invading the muscle layer

digestive/alimentary system
esophageal epithelium hyperplasia ( J:158733 )
• distal esophageal stricture due to squamous cell hyperplasia
esophageal atresia ( J:158733 )
• distal esophageal stricture due to squamous cell hyperplasia




Genotype
MGI:4440865
cx2
Allelic
Composition		 Rab25tm1Jrgo/Rab25tm1Jrgo
Smad3tm1Par/Smad3+
Genetic
Background		 129-Rab25tm1Jrgo Smad3tm1Par
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab25tm1Jrgo mutation (1 available); any Rab25 mutation (18 available)
Smad3tm1Par mutation (2 available); any Smad3 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Colon tumor formation and neoplasia in Rab25tm1Jrgo/Rab25tm1Jrgo Smad3tm1Par/Smad3+ mice

digestive/alimentary system
abnormal colon morphology ( J:158733 )
• the glandular atypia results in numerous mucin-filled cysts in one proximal colon tumor
colon polyps ( J:158733 )
• aberrant or dysplastic crypts, hyperplastic lesions, and adenomatous polyps
abnormal rectum morphology ( J:158733 )
• rectal tumor lesions in 80% of the mice
increased colon adenocarcinoma incidence ( J:158733 )
• large invasive tumor lesions in the proximal colonic mucosa in 80% of the mice
• the colonic epithelial tumors extend into and through the submucosa with neoplastic glands penetrating the muscle wall

neoplasm
increased colon adenocarcinoma incidence ( J:158733 )
• large invasive tumor lesions in the proximal colonic mucosa in 80% of the mice
• the colonic epithelial tumors extend into and through the submucosa with neoplastic glands penetrating the muscle wall

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
colorectal cancer DOID:9256 OMIM:114500
 J:158733




Genotype
MGI:4440863
cx3
Allelic
Composition		 ApcMin/Apc+
Rab25tm1Jrgo/Rab25tm1Jrgo
Genetic
Background		 B6.Cg-Rab25tm1Jrgo ApcMin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Rab25tm1Jrgo mutation (1 available); any Rab25 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Rab25tm1Jrgo/Rab25tm1Jrgo ApcMin/Apc+ mice exhibit increased intestinal adenoma formation compared to ApcMin/Apc+ mice

neoplasm
increased intestinal adenoma incidence ( J:158733 )
• tubular adenomas in the intestine
• 4-fold increase in tumor number throughout the intestines compared with heterozygous Apcmin mice
increased colon adenoma incidence ( J:158733 )
• tubular adenomas in the colon

digestive/alimentary system
colon polyps ( J:158733 )
• 2-fold increase in colonic polyp number compared with heterozygous Apcmin mice
• increased polyp size
• more widely distributed polyps in the colon
increased intestinal adenoma incidence ( J:158733 )
• tubular adenomas in the intestine
• 4-fold increase in tumor number throughout the intestines compared with heterozygous Apcmin mice
increased colon adenoma incidence ( J:158733 )
• tubular adenomas in the colon

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
familial adenomatous polyposis DOID:0050424 OMIM:PS175100
 J:158733




Genotype
MGI:4440864
cx4
Allelic
Composition		 ApcMin/Apc+
Rab25tm1Jrgo/Rab25+
Genetic
Background		 B6.Cg-Rab25tm1Jrgo ApcMin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Rab25tm1Jrgo mutation (1 available); any Rab25 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased intestinal adenoma incidence ( J:158733 )
• 2-fold increase in tumor number in the middle and distal intestines compared with heterozygous Apcmin mice

digestive/alimentary system
increased intestinal adenoma incidence ( J:158733 )
• 2-fold increase in tumor number in the middle and distal intestines compared with heterozygous Apcmin mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory