Phenotypes associated with this allele

• Allele Symbol: Ces1d^tm1Reli
• Allele Name: targeted mutation 1, Richard Lehner
• Allele ID: MGI:4440967
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ces1d^tm1Reli/Ces1d^tm1Reli	involves: 129S6/SvEvTac	MGI:4441039

Genotype
MGI:4441039

hm1

• Allelic Composition: Ces1d^tm1Reli/Ces1d^tm1Reli
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:158743 )

• during insulin tolerance test

abnormal circulating lipid level ( J:158743 )

• fasted and fed mice exhibit decreased plasma concentrations of free cholesterol, cholesteryl esters, and triglyceride compared with wild-type mice

decreased circulating cholesterol level ( J:158743 )

• in fasted and fed mice

decreased circulating VLDL cholesterol level ( J:158743 )

• in fasted and fed mice

decreased circulating free fatty acids level ( J:158743 )

• in fasted and fed mice

decreased circulating glycerol level ( J:158743 )

• in fasted and fed mice

decreased circulating triglyceride level ( J:158743 )

• in fasted and fed mice

decreased circulating VLDL triglyceride level ( J:158743 )

• in fasted and fed mice

increased oxygen consumption ( J:158743 )

increased respiratory quotient ( J:158743 )

• increases

improved glucose tolerance ( J:158743 )

increased insulin sensitivity ( J:158743 )

decreased circulating adiponectin level ( J:158743 )

• in fed mice

decreased liver triglyceride level ( J:158743 )

• in fed mice

liver/biliary system

decreased liver triglyceride level ( J:158743 )

• in fed mice

decreased liver weight ( J:158743 )

• in fasted and fed mice

abnormal hepatocyte physiology ( J:158743 )

• isolated hepatocytes exhibit decreased VLDL secretion compared with wild-type cells

adipose tissue

increased white adipose tissue amount ( J:158743 )

increased white fat cell size ( J:158743 )

• in fasted and fed mice

behavior/neurological

abnormal eating behavior ( J:158743 )

hyperactivity ( J:158743 )

endocrine/exocrine glands

small pancreatic islets ( J:158743 )

• total islet area is decreased compared to in wild-type mice