Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(CAG-Lmx1b,ALPP)Rjo}
• Allele Name: targeted mutation 1, Randy L Johnson
• Allele ID: MGI:4441172
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(CAG-Lmx1b,ALPP)Rjo/Gt(ROSA)26Sor^+ Sox9^tm3(cre)Crm/Sox9^+	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6	MGI:4441200
cn2	Gt(ROSA)26Sor^tm1(CAG-Lmx1b,ALPP)Rjo/Gt(ROSA)26Sor^+ Tg(Prrx1-cre)1Cjt/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J	MGI:4441201

Genotype
MGI:4441200

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Lmx1b,ALPP)Rjo}/Gt(ROSA)26Sor⁺; Sox9^tm3(cre)Crm/Sox9⁺
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal skeleton morphology ( J:158676 )

• tendon elements exhibit a partial ventral to dorsal conversion with ventral cartilaginous protrusions unlike in wild-type mice

abnormal ankle joint morphology ( J:158676 )

• the ventral flexure at the ankle is absent

abnormal tendon morphology ( J:158676 )

• tendon elements exhibit a partial ventral to dorsal conversion with partial conversion of ventral tendon to a dorsal morphology unlike in wild-type mice

• the lateral flexor digitorium profundus tendon is absent unlike in wild-type mice

• the flexor digitorium sublimus is flattened unlike in wild-type mice

muscle

decreased skeletal muscle mass ( J:158676 )

• mice exhibit loss of muscle tissue in the ventral limb unlike wild-type mice

abnormal tendon morphology ( J:158676 )

• tendon elements exhibit a partial ventral to dorsal conversion with partial conversion of ventral tendon to a dorsal morphology unlike in wild-type mice

• the lateral flexor digitorium profundus tendon is absent unlike in wild-type mice

• the flexor digitorium sublimus is flattened unlike in wild-type mice

limbs/digits/tail

abnormal foot pad morphology ( J:158676 )

• mice exhibit hair on the ventral skin of the paw unlike in wild-type mice

abnormal ankle joint morphology ( J:158676 )

• the ventral flexure at the ankle is absent

Genotype
MGI:4441201

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Lmx1b,ALPP)Rjo}/Gt(ROSA)26Sor⁺; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J

skeleton

abnormal skeleton morphology ( J:158676 )

• mice exhibit loss of muscle tissue in the ventral limb unlike wild-type mice

abnormal ankle joint morphology ( J:158676 )

• the ventral flexure at the ankle is absent

abnormal tendon morphology ( J:158676 )

• tendon elements exhibit a partial ventral to dorsal conversion with partial conversion of ventral tendon to a dorsal morphology unlike in wild-type mice

• the lateral flexor digitorium profundus tendon is absent unlike in wild-type mice

• the flexor digitorium sublimus is flattened unlike in wild-type mice

muscle

decreased skeletal muscle mass ( J:158676 )

• mice exhibit loss of muscle tissue in the ventral limb unlike wild-type mice

abnormal tendon morphology ( J:158676 )

• tendon elements exhibit a partial ventral to dorsal conversion with partial conversion of ventral tendon to a dorsal morphology unlike in wild-type mice

• the lateral flexor digitorium profundus tendon is absent unlike in wild-type mice

• the flexor digitorium sublimus is flattened unlike in wild-type mice

limbs/digits/tail

abnormal foot pad morphology ( J:158676 )

• mice exhibit hair on the ventral skin of the paw unlike in wild-type mice

abnormal ankle joint morphology ( J:158676 )

• the ventral flexure at the ankle is absent