Phenotypes associated with this allele

• Allele Symbol: Sp2^tm1Sus
• Allele Name: targeted mutation 1, Guntram Suske
• Allele ID: MGI:4441277
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sp2^tm1Sus/Sp2^tm1Sus	involves: 129P2/OlaHsd * C57BL/6	MGI:4441284

Genotype
MGI:4441284

hm1

• Allelic Composition: Sp2^tm1Sus/Sp2^tm1Sus
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Impaired development of Sp2^tm1Sus/Sp2^tm1Sus embryos

mortality/aging

postnatal lethality, complete penetrance ( J:158671 )

• one (1.1%) homozygous mouse survive to birth, but died two weeks after birth

lethality throughout fetal growth and development, incomplete penetrance ( J:158671 )

• many of the homozygous embryos are already dead at E16.5 and E18.5

growth/size/body

decreased fetal size ( J:158671 )

• smaller homozygous embryos at E16.5 and E18.5

• normal body size at E12.5

fetal growth retardation ( J:158671 )

• developmentally retarded, albeit with considerable variation at E16.5 and E18.5

cardiovascular system

hemorrhage ( J:158671 )

• hemorrhaging, predominantly in the head area at E12.5

• embryos appear apparently normal at E9.5