Phenotypes associated with this allele

• Allele Symbol: Sp2^tm1.2Sus
• Allele Name: targeted mutation 1.2, Guntram Suske
• Allele ID: MGI:4441280
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sp2^tm1.2Sus/Sp2^tm1.2Sus	involves: 129P2/OlaHsd * C57BL/6	MGI:4441287

Genotype
MGI:4441287

hm1

• Allelic Composition: Sp2^tm1.2Sus/Sp2^tm1.2Sus
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small size, failure of embryo turning, and open cranial neural tube in Sp2^tm1.2Sus/Sp2^tm1.2Sus embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:158671 )

• no homozygous embryos are found alive beyond E10.5

growth/size/body

embryonic growth retardation ( J:158671 )

• the appearance of E9.5 embryos is similar to E8.5 wild-type and heterozygous embryos

• growth and developmental retardation are visible at E7.5

decreased embryo size ( J:158671 )

• homozygous embryos are smaller than their littermates at E9.5

cellular

absent fibroblast proliferation ( J:158671 )

• mouse embryonic fibroblasts (MEFs) obtained from E9.5 homozygous embryos do not divide

embryo

abnormal embryo turning ( J:158671 )

• develop until the nine somite stage but fail to undergo body turning at E9.5

embryonic growth retardation ( J:158671 )

• the appearance of E9.5 embryos is similar to E8.5 wild-type and heterozygous embryos

• growth and developmental retardation are visible at E7.5

decreased embryo size ( J:158671 )

• homozygous embryos are smaller than their littermates at E9.5

open neural tube ( J:158671 )

• embryos have an open cranial neural tube at E9

nervous system

open neural tube ( J:158671 )

• embryos have an open cranial neural tube at E9