Phenotypes associated with this allele

• Allele Symbol: Tie1^tm1.1Scba
• Allele Name: targeted mutation 1.1, Scott Baldwin
• Allele ID: MGI:4441288
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tie1^tm1.1Scba/Tie1^tm1.1Scba	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:4441294

Genotype
MGI:4441294

hm1

• Allelic Composition: Tie1^tm1.1Scba/Tie1^tm1.1Scba
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:158668 )

• mice die in utero or at birth

prenatal lethality, incomplete penetrance ( J:158668 )

• mice die in utero or at birth

cardiovascular system

dilated vasculature ( J:158668 )

• mild

hemorrhage ( J:158668 )

homeostasis/metabolism

edema ( J:158668 )

• severe

immune system

abnormal lymphatic vessel morphology ( J:158668 )

• at E13.5, lymphatic defects are more severe than in Tie1^tm1Scba mice

abnormal lymphangiogenesis ( J:158668 )

• at E11.5 and E12.5, proliferation of lymphatic endothelial cells is increased compared to in wild-type mice

• however, proliferation of lymphatic endothelial cells is normal by E13.5 and expression of marks is normal

lymphatic vessel hyperplasia ( J:158668 )

• at E13.5, jugular lymph sacs are larger than in wild-type mice