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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adam22tm1.1Mejr
targeted mutation 1.1, Dies Meijer
MGI:4441313
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Adam22tm1.1Mejr/Adam22tm1.1Mejr
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:4441314
cn2
 		Adam22tm1.1Mejr/Adam22tm1.1Mejr
Tg(Dhh-cre)1Mejr/0 		involves: 129S4/SvJaeSor * FVB/N MGI:4441315


Genotype
MGI:4441314
cn1
Allelic
Composition		 Adam22tm1.1Mejr/Adam22tm1.1Mejr
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam22tm1.1Mejr mutation (0 available); any Adam22 mutation (72 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron morphology ( J:158973 )
• mice exhibit promyelin arrested fibers unlike wild-type mice
abnormal myelination ( J:158973 )
• mice exhibit promyelin arrested fibers unlike wild-type mice




Genotype
MGI:4441315
cn2
Allelic
Composition		 Adam22tm1.1Mejr/Adam22tm1.1Mejr
Tg(Dhh-cre)1Mejr/0
Genetic
Background		 involves: 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam22tm1.1Mejr mutation (0 available); any Adam22 mutation (72 available)
Tg(Dhh-cre)1Mejr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:158973 )
N
• motor neuron myelination is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory