Phenotypes associated with this allele

• Allele Symbol: Sirt7^tm1Fwa
• Allele Name: targeted mutation 1, Frederick W Alt
• Allele ID: MGI:4441347
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sirt7^tm1Fwa/Sirt7^tm1Fwa	involves: 129S1/Sv	MGI:5293363

Genotype
MGI:5293363

hm1

• Allelic Composition: Sirt7^tm1Fwa/Sirt7^tm1Fwa
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

enlarged liver ( J:205529 )

• slightly in mice fed a chow diet

increased liver triglyceride level ( J:205529 )

• 2.5-fold in mice fed a chow diet

abnormal hepatocyte morphology ( J:205529 )

• vacuolated with accumulation of fat in mice fed a chow diet

hepatic steatosis ( J:205529 )

• in mice fed a chow diet

pale liver ( J:205529 )

• in mice fed a chow diet

abnormal liver physiology ( J:205529 )

• increased endoplasmic reticulum (ER) stress in livers of mice fed a chow diet

• however, liver-specific reconstitution rescues ER stress

liver inflammation ( J:205529 )

• increased macrophage infiltration indicating progression to steatohepatitis in mice fed a chow diet

• however, liver-specific reconstitution rescues development of hepatosteatosis

homeostasis/metabolism

abnormal lipid homeostasis ( J:205529 )

• increased lipogenesis in the liver of mice fed a chow diet

decreased circulating triglyceride level ( J:205529 )

• 4-fold in mice fed a chow diet

• however, triglyceride levels in feces are normal

decreased circulating VLDL triglyceride level ( J:205529 )

• in mice fed a chow diet

increased liver triglyceride level ( J:205529 )

• 2.5-fold in mice fed a chow diet

adipose tissue

decreased epididymal fat pad weight ( J:205529 )

• in mice fed a chow diet

behavior/neurological

increased food intake ( J:205529 )

• in mice fed a chow diet

growth/size/body

decreased body weight ( J:205529 )

• in mice fed a chow diet

enlarged liver ( J:205529 )

• slightly in mice fed a chow diet

immune system

increased macrophage cell number ( J:205529 )

• in the liver as determined by F4/F80 staining in mice fed a chow diet

liver inflammation ( J:205529 )

• increased macrophage infiltration indicating progression to steatohepatitis in mice fed a chow diet

• however, liver-specific reconstitution rescues development of hepatosteatosis

hematopoietic system

increased macrophage cell number ( J:205529 )

• in the liver as determined by F4/F80 staining in mice fed a chow diet