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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Flt4tm1.1Ichi
targeted mutation 1.1, Hirotake Ichise
MGI:4441407
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Flt4tm1.1Ichi/Flt4+ B6.Cg-Flt4tm1.1Ichi MGI:4821321
cx2
 		Flt4tm1.1Ichi/Flt4+
Tg(HRAS)2Jic/0 		involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2 MGI:4821322
cx3
 		Flt4tm1.1Ichi/Flt4+
Krastm1Mok/Kras+
Tg(HRAS)2Jic/0 		involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2 MGI:4821326
cx4
 		Flt4tm1.1Ichi/Flt4+
Krastm1Mok/Kras+ 		involves: 129S/SvEv * C57BL/6 MGI:4821325


Genotype
MGI:4821321
ht1
Allelic
Composition		 Flt4tm1.1Ichi/Flt4+
Genetic
Background		 B6.Cg-Flt4tm1.1Ichi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1.1Ichi mutation (0 available); any Flt4 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
chylous ascites ( J:159024 )
• 7 of 28 mice develop chylous ascites unlike wild-type mice




Genotype
MGI:4821322
cx2
Allelic
Composition		 Flt4tm1.1Ichi/Flt4+
Tg(HRAS)2Jic/0
Genetic
Background		 involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1.1Ichi mutation (0 available); any Flt4 mutation (76 available)
Tg(HRAS)2Jic mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:159024 )
N
• no mice exhibit chylous ascites




Genotype
MGI:4821326
cx3
Allelic
Composition		 Flt4tm1.1Ichi/Flt4+
Krastm1Mok/Kras+
Tg(HRAS)2Jic/0
Genetic
Background		 involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1.1Ichi mutation (0 available); any Flt4 mutation (76 available)
Krastm1Mok mutation (6 available); any Kras mutation (76 available)
Tg(HRAS)2Jic mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
chylous ascites ( J:159024 )
• 1 of 13 mice develop chylous ascites unlike wild-type mice

immune system
lymphatic vessel hypoplasia ( J:159024 )
• a few mice exhibit lymphatic vessel hypoplasia




Genotype
MGI:4821325
cx4
Allelic
Composition		 Flt4tm1.1Ichi/Flt4+
Krastm1Mok/Kras+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1.1Ichi mutation (0 available); any Flt4 mutation (76 available)
Krastm1Mok mutation (6 available); any Kras mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
lymphedema ( J:159024 )
• intestinal
chylous ascites ( J:159024 )
• all mice develop chylous ascites unlike wild-type mice

immune system
lymphatic vessel hypoplasia ( J:159024 )
• mice develop lymphatic vessel hypoplasia unlike wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory