Phenotypes associated with this allele

• Allele Symbol: Flt4^tm1.1Ichi
• Allele Name: targeted mutation 1.1, Hirotake Ichise
• Allele ID: MGI:4441407
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Flt4^tm1.1Ichi/Flt4^+	B6.Cg-Flt4^tm1.1Ichi	MGI:4821321
cx2	Flt4^tm1.1Ichi/Flt4^+ Tg(HRAS)2Jic/0	involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2	MGI:4821322
cx3	Flt4^tm1.1Ichi/Flt4^+ Kras^tm1Mok/Kras^+ Tg(HRAS)2Jic/0	involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2	MGI:4821326
cx4	Flt4^tm1.1Ichi/Flt4^+ Kras^tm1Mok/Kras^+	involves: 129S/SvEv * C57BL/6	MGI:4821325

Genotype
MGI:4821321

ht1

• Allelic Composition: Flt4^tm1.1Ichi/Flt4⁺
• Genetic Background: B6.Cg-Flt4^tm1.1Ichi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

chylous ascites ( J:159024 )

• 7 of 28 mice develop chylous ascites unlike wild-type mice

Genotype
MGI:4821322

cx2

• Allelic Composition: Flt4^tm1.1Ichi/Flt4⁺; Tg(HRAS)2Jic/0
• Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:159024 )

N • no mice exhibit chylous ascites

Genotype
MGI:4821326

cx3

• Allelic Composition: Flt4^tm1.1Ichi/Flt4⁺; Kras^tm1Mok/Kras⁺; Tg(HRAS)2Jic/0
• Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2

homeostasis/metabolism

chylous ascites ( J:159024 )

• 1 of 13 mice develop chylous ascites unlike wild-type mice

immune system

lymphatic vessel hypoplasia ( J:159024 )

• a few mice exhibit lymphatic vessel hypoplasia

Genotype
MGI:4821325

cx4

• Allelic Composition: Flt4^tm1.1Ichi/Flt4⁺; Kras^tm1Mok/Kras⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

homeostasis/metabolism

lymphedema ( J:159024 )

• intestinal

chylous ascites ( J:159024 )

• all mice develop chylous ascites unlike wild-type mice

immune system

lymphatic vessel hypoplasia ( J:159024 )

• mice develop lymphatic vessel hypoplasia unlike wild-type mice