All Phenotypes Myo1e<tm1Flv> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Myo1e^tm1Flv/Myo1e^tm1Flv Tg(NPHS2-cre)295Lbh/0	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:5445941
cn2	Myo1e^tm1Flv/Myo1e^tm1.1Flv Tg(NPHS2-cre)295Lbh/0	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:5445942

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

albuminuria ( J:188500 )

• on a predominantly C57BL/6 background, many mice develop albuminuria by 8 weeks of age

• however, some mice that retain Myo1e expression in podocytes, as confirmed by immunostaining, do not exhibit albuminuria; a number of these maintain normal urinary protein excretion up to 6-8 months of age

abnormal podocyte foot process morphology ( J:188500 )

• by 4 months of age, the average number of foot processes per unit length of the basement membrane is lower than that in controls

podocyte foot process effacement ( J:188500 )

• at 2 months of age, proteinuric mice exhibit only a few areas of foot process effacement

• by 4 months of age, pronounced foot process effacement is observed, unlike in control mice

abnormal renal glomerulus basement membrane morphology ( J:188500 )

• by 4 months of age, the overall outline of the GBM appears jagged and uneven, unlike in control mice

increased renal glomerulus basement membrane thickness ( J:188500 )

• at 2 months of age, proteinuric mice exhibit only a few areas of GBM thickening

• by 4 months of age, average GBM thickness is increased relative to that in controls

glomerulosclerosis ( J:188500 )

• at 8 months of age, mice exhibit some sclerotic glomeruli, unlike control mice

• however, no glomerulosclerosis is seen at 4 months

renal cast ( J:188500 )

• at 8 months of age, mice exhibit a few proteinaceous casts, unlike control mice

• however, no renal casts are seen at 4 months

homeostasis/metabolism

albuminuria ( J:188500 )

• on a predominantly C57BL/6 background, many mice develop albuminuria by 8 weeks of age

Allelic Composition	Myo1e^tm1Flv/Myo1e^tm1.1Flv Tg(NPHS2-cre)295Lbh/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo1e^tm1.1Flv mutation (1 available); any Myo1e mutation (91 available)
Myo1e^tm1Flv mutation (1 available); any Myo1e mutation (91 available)
Tg(NPHS2-cre)295Lbh mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

albuminuria ( J:188500 )

• on a predominantly C57BL/6 background, mice develop moderate albuminuria by 8 weeks of age, while control mice show no evidence of albuminuria up to 6 months of age

• however, at 2-6 months of age, mice exhibit significantly lower albumin:creatinine ratios than those observed in Myo1e^tm1.1Flv homozygotes

glomerulosclerosis ( J:188500 )

• at 7 months of age, mice exhibit some sclerotic glomeruli, unlike control mice

renal cast ( J:188500 )

• at 7 months of age, mice exhibit a few proteinaceous casts, unlike control mice

homeostasis/metabolism

albuminuria ( J:188500 )

• on a predominantly C57BL/6 background, mice develop moderate albuminuria by 8 weeks of age, while control mice show no evidence of albuminuria up to 6 months of age

• however, at 2-6 months of age, mice exhibit significantly lower albumin:creatinine ratios than those observed in Myo1e^tm1.1Flv homozygotes

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