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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myo1etm1.1Flv
targeted mutation 1.1, Richard A Flavell
MGI:4441413
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Myo1etm1.1Flv/Myo1etm1.1Flv B6.129S6-Myo1etm1.1Flv MGI:5445938
hm2
 		Myo1etm1.1Flv/Myo1etm1.1Flv involves: 129S6/SvEvTac MGI:4441448
cn3
 		Myo1etm1Flv/Myo1etm1.1Flv
Tg(NPHS2-cre)295Lbh/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:5445942


Genotype
MGI:5445938
hm1
Allelic
Composition		 Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic
Background		 B6.129S6-Myo1etm1.1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo1etm1.1Flv mutation (1 available); any Myo1e mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
albuminuria ( J:188500 )
• as early as 4 weeks of age, mice exhibit significantly higher urinary albumin:creatinine ratios relative to wild-type controls
• at 2-6 months of age, albumin:creatinine ratios are significantly higher than those in podocyte-specific knockouts generated on a predominantly C57BL/6 background
abnormal podocyte foot process morphology ( J:188500 )
• by 4 months of age, the average number of foot processes per unit length of the basement membrane is reduced relative to than in wild-type controls
podocyte foot process effacement ( J:188500 )
• as early as 2 months of age, mice exhibit widespread foot process effacement, unlike wild-type controls
podocyte microvillus transformation ( J:188500 )
• by 4 months of age, podocytes exhibit microvillus transformation, indicating damage
abnormal renal glomerulus basement membrane morphology ( J:188500 )
• as early as 2 months of age, mice exhibit significant GBM alterations relative to wild-type controls
• by 4 months of age, a highly variable GBM disorganization with characteristic electronlucent or "moth-eaten" regions is observed, unlike in wild-type controls
• the overall GBM outline appears jagged and uneven
increased renal glomerulus basement membrane thickness ( J:188500 )
• by 4 months of age, average GBM thickness is increased relative to that in wild-type controls
glomerulosclerosis ( J:188500 )
• at 4 months of age, mice exhibit multiple sclerotic glomeruli, unlike control mice
renal cast ( J:188500 )
• at 4 months of age, mice exhibit multiple renal casts, unlike control mice

homeostasis/metabolism
albuminuria ( J:188500 )
• as early as 4 weeks of age, mice exhibit significantly higher urinary albumin:creatinine ratios relative to wild-type controls
• at 2-6 months of age, albumin:creatinine ratios are significantly higher than those in podocyte-specific knockouts generated on a predominantly C57BL/6 background




Genotype
MGI:4441448
hm2
Allelic
Composition		 Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo1etm1.1Flv mutation (1 available); any Myo1e mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal urine homeostasis ( J:159163 )
• unlike in wild-type mice, urine contains protein (mostly albumin), blood/hemoglobin, and leukocytes
albuminuria ( J:159163 )
• beginning at 3 weeks of age, albumin excretion is increased compared to in wild-type mice
abnormal podocyte foot process morphology ( J:159163 )
• the average number of foot processes per unit length of basement membrane is decreased 2.6-fold compared to in wild-type mice
• however, slit diaphragms are present
podocyte foot process effacement ( J:159163 )
• as early as 3 weeks of age
increased renal glomerulus basement membrane thickness ( J:159163 )
• as early as 1 week of age, mice exhibit increased glomeruli basement membrane thickness compared with wild-type mice
• the thickness of the basement membrane is increased 2-fold and disrupted compared to in wild-type mice
• however, there is no accumulation of immunoglobins
abnormal renal glomerulus morphology ( J:159163 )
• as early as 1 week of age, mice exhibit abnormal glomerular ultrastructure compared with wild-type mice
abnormal glomerular capillary morphology ( J:159163 )
• closed capillary loops, partially obstructed by extracellular matrix, are observed
expanded mesangial matrix ( J:159163 )
• mice display excess extracellular matrix deposition in and around glomeruli unlike wild-type mice
glomerulosclerosis ( J:159163 )
• mice exhibit thickened glomeruli with closed capillary loops partially obstructed by extracellular matrix
abnormal proximal convoluted tubule morphology ( J:159163 )
• mice exhibit signs of tubular injury with loss of apical brush border unlike wild-type mice
proximal convoluted tubule brush border loss ( J:159163 )
• mice exhibit loss of apical brush border unlike wild-type mice
renal cast ( J:159163 )
• periodic acid-Schiff-positive casts in renal tubules
• periodic acid-Schiff-positive protein resorption droplets in proximal tubules
abnormal renal glomerular filtration rate ( J:159163 )
• within the first month of life

homeostasis/metabolism
abnormal urine homeostasis ( J:159163 )
• unlike in wild-type mice, urine contains protein (mostly albumin), blood/hemoglobin, and leukocytes
albuminuria ( J:159163 )
• beginning at 3 weeks of age, albumin excretion is increased compared to in wild-type mice

cardiovascular system
abnormal glomerular capillary morphology ( J:159163 )
• closed capillary loops, partially obstructed by extracellular matrix, are observed

growth/size/body
enlarged kidney ( J:159163 )
increased kidney weight ( J:159163 )
• 1.5-fold




Genotype
MGI:5445942
cn3
Allelic
Composition		 Myo1etm1Flv/Myo1etm1.1Flv
Tg(NPHS2-cre)295Lbh/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo1etm1.1Flv mutation (1 available); any Myo1e mutation (91 available)
Myo1etm1Flv mutation (1 available); any Myo1e mutation (91 available)
Tg(NPHS2-cre)295Lbh mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
albuminuria ( J:188500 )
• on a predominantly C57BL/6 background, mice develop moderate albuminuria by 8 weeks of age, while control mice show no evidence of albuminuria up to 6 months of age
• however, at 2-6 months of age, mice exhibit significantly lower albumin:creatinine ratios than those observed in Myo1etm1.1Flv homozygotes
glomerulosclerosis ( J:188500 )
• at 7 months of age, mice exhibit some sclerotic glomeruli, unlike control mice
renal cast ( J:188500 )
• at 7 months of age, mice exhibit a few proteinaceous casts, unlike control mice

homeostasis/metabolism
albuminuria ( J:188500 )
• on a predominantly C57BL/6 background, mice develop moderate albuminuria by 8 weeks of age, while control mice show no evidence of albuminuria up to 6 months of age
• however, at 2-6 months of age, mice exhibit significantly lower albumin:creatinine ratios than those observed in Myo1etm1.1Flv homozygotes




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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory