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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fntbtm1.1Mbrg
targeted mutation 1.1, Martin O Bergo
MGI:4441481
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fntbtm1.1Mbrg/Fntbtm1.1Mbrg involves: 129P2/OlaHsd * C57BL/6 MGI:4441485
cn2
 		Fntbtm1.1Mbrg/Fntbtm1.2Mbrg involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * FVB/N MGI:4441484
cn3
 		Fntbtm1.1Mbrg/Fntbtm1.2Mbrg
Krastm4Tyj/Kras+ 		involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N MGI:4441486
cn4
 		Fntbtm1.1Mbrg/Fntbtm1.2Mbrg
Krastm4Tyj/Kras+
Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N MGI:4441488
cn5
 		Fntbtm1.1Mbrg/Fntbtm1.2Mbrg
Krastm4Tyj/Kras+
Pggt1btm1Mbrg/Pggt1btm1.1Mbrg 		involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N MGI:4441490
cn6
 		Fntbtm1.1Mbrg/Fntbtm1.2Mbrg
Krastm4Tyj/Kras+
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N MGI:4441492
cn7
 		Fntbtm1.1Mbrg/Fntbtm1.1Mbrg
Pggt1btm1Mbrg/Pggt1btm1Mbrg 		involves: 129P2/OlaHsd * C57BL/6 MGI:4441487
cn8
 		Fntbtm1.1Mbrg/Fntbtm1.1Mbrg
Tg(KRT14-cre)1Amc/? 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:4442842
cn9
 		Fntbtm1.1Mbrg/Fntbtm1.1Mbrg
Pggt1btm1Mbrg/Pggt1btm1Mbrg
Tg(KRT14-cre)1Amc/? 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:4442843


Genotype
MGI:4441485
cn1
Allelic
Composition		 Fntbtm1.1Mbrg/Fntbtm1.1Mbrg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntbtm1.1Mbrg mutation (0 available); any Fntb mutation (208 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell morphology ( J:158937 )
• following Cre-adenovirus treatment, embryonic fibroblasts are large and flat
abnormal cell cycle ( J:158937 )
• following Cre-adenovirus treatment, embryonic fibroblasts accumulate in the G2M phase of the cell cycle
decreased fibroblast proliferation ( J:158937 )
• reduced proliferation in primary embryonic fibroblasts, following Cre-adenovirus treatment




Genotype
MGI:4441484
cn2
Allelic
Composition		 Fntbtm1.1Mbrg/Fntbtm1.2Mbrg
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntbtm1.1Mbrg mutation (0 available); any Fntb mutation (208 available)
Fntbtm1.2Mbrg mutation (0 available); any Fntb mutation (208 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell morphology ( J:158937 )
• following Cre-adenovirus treatment, embryonic fibroblasts are large and flat
abnormal cell cycle ( J:158937 )
• following Cre-adenovirus treatment, embryonic fibroblasts accumulate in the G2M phase of the cell cycle
decreased fibroblast proliferation ( J:158937 )
• reduced proliferation in primary embryonic fibroblasts, following Cre-adenovirus treatment




Genotype
MGI:4441486
cn3
Allelic
Composition		 Fntbtm1.1Mbrg/Fntbtm1.2Mbrg
Krastm4Tyj/Kras+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntbtm1.1Mbrg mutation (0 available); any Fntb mutation (208 available)
Fntbtm1.2Mbrg mutation (0 available); any Fntb mutation (208 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:158937 )
• Cre-adenovirus treatment results in G2M cell-cycle arrest in embryonic fibroblasts




Genotype
MGI:4441488
cn4
Allelic
Composition		 Fntbtm1.1Mbrg/Fntbtm1.2Mbrg
Krastm4Tyj/Kras+
Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntbtm1.1Mbrg mutation (0 available); any Fntb mutation (208 available)
Fntbtm1.2Mbrg mutation (0 available); any Fntb mutation (208 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Pggt1btm1.1Mbrg mutation (0 available); any Pggt1b mutation (27 available)
Pggt1btm1Mbrg mutation (0 available); any Pggt1b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:158937 )
• median life span is 170 days
• longer median life span than Lyz2tm1(cre)Ifo, Krastm4Tyj heterozygous mice (170 vs. 22 days)

neoplasm
decreased tumor growth/size ( J:158937 )
• lung weight and histology are indistinguishable from littermate control mice at 3-week old, compare with lung weight is 10-fold higher in Lyz2tm1(cre)Ifo, Krastm4Tyj heterozygous mice
increased lung tumor incidence ( J:158937 )
• lung weight and histology are indistinguishable from littermate control mice at 3-week old
• but eventually develop lung tumors at older age

respiratory system
increased lung tumor incidence ( J:158937 )
• lung weight and histology are indistinguishable from littermate control mice at 3-week old
• but eventually develop lung tumors at older age




Genotype
MGI:4441490
cn5
Allelic
Composition		 Fntbtm1.1Mbrg/Fntbtm1.2Mbrg
Krastm4Tyj/Kras+
Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntbtm1.1Mbrg mutation (0 available); any Fntb mutation (208 available)
Fntbtm1.2Mbrg mutation (0 available); any Fntb mutation (208 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Pggt1btm1.1Mbrg mutation (0 available); any Pggt1b mutation (27 available)
Pggt1btm1Mbrg mutation (0 available); any Pggt1b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor growth/size ( J:158937 )
• 76% fewer tumors and 79% smaller lesion area than Krastm4Tyj heterozygous mice after Cre-adenovirus treatment
increased lung tumor incidence ( J:158937 )
• the lung surface of Cre-adenovirus treated mice is nearly indistinguishable from that of control mice
• 76% fewer tumors and 79% smaller lesion area than Krastm4Tyj heterozygous mice after Cre-adenovirus treatment
increased lung adenoma incidence ( J:158937 )
• presence of small adenomas after Cre-adenovirus treatment
increased lung carcinoma incidence ( J:158937 )
• adenocarcinoma in 1 of 11 mice after Cre-adenovirus treatment

respiratory system
increased lung tumor incidence ( J:158937 )
• the lung surface of Cre-adenovirus treated mice is nearly indistinguishable from that of control mice
• 76% fewer tumors and 79% smaller lesion area than Krastm4Tyj heterozygous mice after Cre-adenovirus treatment
increased lung adenoma incidence ( J:158937 )
• presence of small adenomas after Cre-adenovirus treatment
increased lung carcinoma incidence ( J:158937 )
• adenocarcinoma in 1 of 11 mice after Cre-adenovirus treatment
abnormal lung epithelium morphology ( J:158937 )
• presence of epithelial hyperplasia after Cre-adenovirus treatment




Genotype
MGI:4441492
cn6
Allelic
Composition		 Fntbtm1.1Mbrg/Fntbtm1.2Mbrg
Krastm4Tyj/Kras+
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntbtm1.1Mbrg mutation (0 available); any Fntb mutation (208 available)
Fntbtm1.2Mbrg mutation (0 available); any Fntb mutation (208 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:158937 )
• longer life span than Lyz2tm1(cre)Ifo, Krastm4Tyj heterozygous mice (>100 days in some cases)

respiratory system
increased lung weight ( J:158937 )
• lung weight is less than Lyz2tm1(cre)Ifo, Krastm4Tyj heterozygous mice but higher than in normal mice

neoplasm
decreased tumor growth/size ( J:158937 )
• lung weight is less than Lyz2tm1(cre)Ifo, Krastm4Tyj heterozygous mice

growth/size/body
increased lung weight ( J:158937 )
• lung weight is less than Lyz2tm1(cre)Ifo, Krastm4Tyj heterozygous mice but higher than in normal mice




Genotype
MGI:4441487
cn7
Allelic
Composition		 Fntbtm1.1Mbrg/Fntbtm1.1Mbrg
Pggt1btm1Mbrg/Pggt1btm1Mbrg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntbtm1.1Mbrg mutation (0 available); any Fntb mutation (208 available)
Pggt1btm1Mbrg mutation (0 available); any Pggt1b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased fibroblast apoptosis ( J:158937 )
• Cre-adenovirus treatment results in apoptosis in embryonic fibroblasts within 4 days
• Cre-adenovirus treatment results in apoptosis in embryonic fibroblasts expressing oncogenic H-RAS in the plasma membrane




Genotype
MGI:4442842
cn8
Allelic
Composition		 Fntbtm1.1Mbrg/Fntbtm1.1Mbrg
Tg(KRT14-cre)1Amc/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntbtm1.1Mbrg mutation (0 available); any Fntb mutation (208 available)
Tg(KRT14-cre)1Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:158528 )
• most of the hair shafts are dysmorphic
• all of the layers of the shaft develop but the shafts are smaller and not as straight as in controls

integument
increased hair follicle apoptosis ( J:158528 )
• apoptotic cells are detected in the hair follicle at P1 and are even more numerous at P4, P6 and P8
• scattered apoptotic cells are detected in the interfollicular epidermis at P4, P6 and P8
decreased keratinocyte proliferation ( J:158528 )
• marked proliferation defect in culture cells
alopecia ( J:158528 )
• by P6 alopecia is virtually complete and persists throughout life
underdeveloped hair follicles ( J:158528 )
• hair follicles are stunted in appearance
• hair follicles appear normal at E17.5 but stunting of hair follicles is easily apparent at all post-natal time points
abnormal hair follicle orientation ( J:158528 )
• most of the hair shafts are improperly angled and few penetrated the surface of the skin
decreased hair follicle number ( J:158528 )
• hair follicles have largely disappeared by P120
abnormal keratinocyte morphology ( J:158528 )
• keratinocytes in culture have a flattened morphology

cellular
increased hair follicle apoptosis ( J:158528 )
• apoptotic cells are detected in the hair follicle at P1 and are even more numerous at P4, P6 and P8
• scattered apoptotic cells are detected in the interfollicular epidermis at P4, P6 and P8
decreased keratinocyte proliferation ( J:158528 )
• marked proliferation defect in culture cells




Genotype
MGI:4442843
cn9
Allelic
Composition		 Fntbtm1.1Mbrg/Fntbtm1.1Mbrg
Pggt1btm1Mbrg/Pggt1btm1Mbrg
Tg(KRT14-cre)1Amc/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntbtm1.1Mbrg mutation (0 available); any Fntb mutation (208 available)
Pggt1btm1Mbrg mutation (0 available); any Pggt1b mutation (27 available)
Tg(KRT14-cre)1Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
decreased hair follicle number ( J:158528 )
• at E17.5 embryos have fewer hair follicles
thin epidermis ( J:158528 )
• interfollicular epidermis is slightly thinner compared to either single mutant at E17.5
abnormal skin physiology ( J:158528 )
• at E17.5 more apoptotic cells are present than in either single mutant




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory