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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cdh23tm1.2Ugds
targeted mutation 1.2, Unite de Genetique des Deficits Sensoriels
MGI:4441515
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cdh23tm1.2Ugds/Cdh23tm1.2Ugds involves: 129S1/SvImJ MGI:4950050
hm2
Cdh23tm1.2Ugds/Cdh23tm1.2Ugds involves: 129S1/SvImJ * BALB/c * C57BL/6 MGI:4441519


Genotype
MGI:4950050
hm1
Allelic
Composition
Cdh23tm1.2Ugds/Cdh23tm1.2Ugds
Genetic
Background
involves: 129S1/SvImJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh23tm1.2Ugds mutation (0 available); any Cdh23 mutation (281 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• absent from inner and outer hair cells at P5

nervous system
• absent from inner and outer hair cells at P5




Genotype
MGI:4441519
hm2
Allelic
Composition
Cdh23tm1.2Ugds/Cdh23tm1.2Ugds
Genetic
Background
involves: 129S1/SvImJ * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh23tm1.2Ugds mutation (0 available); any Cdh23 mutation (281 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• at P5, outer hair cell fold angle peaks at zero degrees indicating no detectable concavity unlike in wild-type mice
• the contour of the cuticular plate remains convex unlike in wild-type mice
• outer hair cells exhibit a slight flattening of their neural and abneural sides compared to in wild-type mice
• hair bundles are fragmented compared to in wild-type mice

nervous system
• at P5, outer hair cell fold angle peaks at zero degrees indicating no detectable concavity unlike in wild-type mice
• the contour of the cuticular plate remains convex unlike in wild-type mice
• outer hair cells exhibit a slight flattening of their neural and abneural sides compared to in wild-type mice
• hair bundles are fragmented compared to in wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory