Phenotypes associated with this allele

• Allele Symbol: Terf2ip^tm1.2Tdl
• Allele Name: targeted mutation 1.2, Titia de Lange
• Allele ID: MGI:4441596
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Terf2ip^tm1.2Tdl/Terf2ip^tm1.2Tdl	involves: C57BL/6J * FVB/N	MGI:4441599

Genotype
MGI:4441599

hm1

• Allelic Composition: Terf2ip^tm1.2Tdl/Terf2ip^tm1.2Tdl
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:158884 )

N • mice are fertile

mortality/aging

mortality/aging ( J:199372 )

N • no signs of accelerated aging within the first year of life

cellular

cellular phenotype ( J:158884 , J:199372 )

N • mouse embryonic fibroblasts exhibit normal proliferation (J:158884)

N • no telomere dysfunction (J:199372)

growth/size/body

obese ( J:199372 )

• adult onset

abnormal susceptibility to weight gain ( J:199372 )

• gradual increase in body weight of females (noticeable by approximately 22 weeks of age), less noticeable in male; significant at approximately 34 weeks

• however, no difference in food intake is detected compared to controls

liver/biliary system

hepatic steatosis ( J:199372 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:199372 )

N • unaffected body temperature maintenance when subjected to cold challenge in 6-8 weeks old mice

increased circulating glucose level ( J:199372 )

• significant increase in fasting blood glucose

increased circulating insulin level ( J:199372 )

• significant increase of plasma insulin

impaired glucose tolerance ( J:199372 )

insulin resistance ( J:199372 )

increased cholesterol level ( J:199372 )

• significant

adipose tissue

increased subcutaneous adipose tissue amount ( J:199372 )

• excess accumulation of subcutaneous fat

increased abdominal adipose tissue amount ( J:199372 )

• excess accumulation of intra-abdominal fat

abnormal abdominal fat pad morphology ( J:199372 )

• increase size of white adipose tissue (6 weeks old)

• no change in brown adipose tissue is detected

increased abdominal fat pad weight ( J:199372 )

• 24- to 32-weeks old

increased percent body fat/body weight ( J:199372 )

• at 24 - 32 weeks of age

integument

increased subcutaneous adipose tissue amount ( J:199372 )

• excess accumulation of subcutaneous fat