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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptprcltng
lightning
MGI:4441612
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptprcltng/Ptprcltng C57BL/6-Ptprcltng MGI:4442175
ht2
 		Ptprcltng/Ptprctm1Mak involves: 129/Sv * C57BL/6 MGI:4442177
cx3
 		Csktm1Sor/Csk+
Ptprcltng/Ptprcltng 		involves: 129S7/SvEvBrd * C57BL/6 MGI:4442176
cx4
 		Csktm1Sor/Csk+
Ptprcltng/Ptprctm1Mak 		involves: 129S7/SvEvBrd * C57BL/6 MGI:4442178
cx5
 		Ptprcltng/Ptprctm1Mak
Tg(TcraTcrb)425Cbn/0 		involves: 129/Sv * BALB/c * C57BL/6 MGI:4442182


Genotype
MGI:4442175
hm1
Allelic
Composition		 Ptprcltng/Ptprcltng
Genetic
Background		 C57BL/6-Ptprcltng
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprcltng mutation (3 available); any Ptprc mutation (189 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:158876 )
• mice exhibit enhanced negative selection compared with wild-type mice
• positive selection of T cell is rescued and single positive thymic subsets compared to in Ptprctm1Mak homozygotes
decreased CD4-positive, alpha-beta T cell number ( J:158876 )
• SP4 thymocytes are reduced compared to in wild-type mice

hematopoietic system
abnormal T cell differentiation ( J:158876 )
• mice exhibit enhanced negative selection compared with wild-type mice
• positive selection of T cell is rescued and single positive thymic subsets compared to in Ptprctm1Mak homozygotes
decreased CD4-positive, alpha-beta T cell number ( J:158876 )
• SP4 thymocytes are reduced compared to in wild-type mice

endocrine/exocrine glands




Genotype
MGI:4442177
ht2
Allelic
Composition		 Ptprcltng/Ptprctm1Mak
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprcltng mutation (3 available); any Ptprc mutation (189 available)
Ptprctm1Mak mutation (2 available); any Ptprc mutation (189 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:158876 )
• mice exhibit enhanced negative selection compared with wild-type mice
• positive selection of T cell is rescued and single positive thymic subsets compared to in Ptprctm1Mak homozygotes
decreased CD4-positive, alpha-beta T cell number ( J:158876 )
• SP4 thymocytes are reduced compared to in wild-type mice

hematopoietic system
abnormal T cell differentiation ( J:158876 )
• mice exhibit enhanced negative selection compared with wild-type mice
• positive selection of T cell is rescued and single positive thymic subsets compared to in Ptprctm1Mak homozygotes
decreased CD4-positive, alpha-beta T cell number ( J:158876 )
• SP4 thymocytes are reduced compared to in wild-type mice

endocrine/exocrine glands




Genotype
MGI:4442176
cx3
Allelic
Composition		 Csktm1Sor/Csk+
Ptprcltng/Ptprcltng
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csktm1Sor mutation (2 available); any Csk mutation (27 available)
Ptprcltng mutation (3 available); any Ptprc mutation (189 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system

endocrine/exocrine glands




Genotype
MGI:4442178
cx4
Allelic
Composition		 Csktm1Sor/Csk+
Ptprcltng/Ptprctm1Mak
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csktm1Sor mutation (2 available); any Csk mutation (27 available)
Ptprcltng mutation (3 available); any Ptprc mutation (189 available)
Ptprctm1Mak mutation (2 available); any Ptprc mutation (189 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:158876 )
• ligand-independent signaling checkpoint in T cell development is rescued compared to in Ptprcltng/Ptprctm1Mak heterozygotes and comparable to in Ptprcltng homozygotes

hematopoietic system
abnormal T cell differentiation ( J:158876 )
• ligand-independent signaling checkpoint in T cell development is rescued compared to in Ptprcltng/Ptprctm1Mak heterozygotes and comparable to in Ptprcltng homozygotes

endocrine/exocrine glands




Genotype
MGI:4442182
cx5
Allelic
Composition		 Ptprcltng/Ptprctm1Mak
Tg(TcraTcrb)425Cbn/0
Genetic
Background		 involves: 129/Sv * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprcltng mutation (3 available); any Ptprc mutation (189 available)
Ptprctm1Mak mutation (2 available); any Ptprc mutation (189 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:158876 )
• fewer Tg(TcraTcrb)425Cbn CD4+ T cells develop compared to in wild-type Tg(TcraTcrb)425Cbn mice

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:158876 )
• fewer Tg(TcraTcrb)425Cbn CD4+ T cells develop compared to in wild-type Tg(TcraTcrb)425Cbn mice

endocrine/exocrine glands




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory