All Phenotypes Chrna3<tm1.1Hwrt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Chrna3^tm1.1Hwrt
targeted mutation 1.1, Edward Hawrot
MGI:4442209

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chrna3^tm1.1Hwrt/Chrna3^tm1.1Hwrt	B6.129S7-Chrna3^tm1.1Hwrt	MGI:4442223
hm2	Chrna3^tm1.1Hwrt/Chrna3^tm1.1Hwrt	involves: 129S1/Sv * 129S7/SvEvBrd * BALB/c * C57BL/6	MGI:4442220
hm3	Chrna3^tm1.1Hwrt/Chrna3^tm1.1Hwrt	involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * CD-1	MGI:4442221
hm4	Chrna3^tm1.1Hwrt/Chrna3^tm1.1Hwrt	involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * ICR	MGI:4442222
cx5	Chrna3^tm1.1Hwrt/Chrna3^tm1.1Hwrt Chrna7^tm1Bay/Chrna7^tm1Bay	involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6	MGI:4442219

Allelic Composition	Chrna3^tm1.1Hwrt/Chrna3^tm1.1Hwrt
Genetic Background	B6.129S7-Chrna3^tm1.1Hwrt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna3^tm1.1Hwrt mutation (1 available); any Chrna3 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:157611 )

• Background Sensitivity: all mice on a C57BL/6 inbred background are dead by 3 months of age of unknown causes unlike on an outbred background

• Background Sensitivity: less than 2% of mice on a C57BL/6 inbred background survive at P70 compared to 60% on an outbred background

postnatal lethality, incomplete penetrance ( J:157611 )

• 50% of mice on a C57BL/6 inbred background die prior to 1 to 2 weeks of age unlike on outbred backgrounds

growth/size/body

decreased body size ( J:157611 )

• Background Sensitivity: mice are runted on a C57BL/6 inbred background unlike normal-sized mice on a mixed background containing BALB/c

renal/urinary system

hydronephrosis ( J:157611 )

• mild

Allelic Composition	Chrna3^tm1.1Hwrt/Chrna3^tm1.1Hwrt
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna3^tm1.1Hwrt mutation (1 available); any Chrna3 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:157611 )

• Background Sensitivity: 60% of mice survive at P70 on a mixed background compared to less than 2% on a C57BL/6 inbred background

growth/size/body

growth/size/body region phenotype ( J:157611 )

N	• Background Sensitivity: mice are of normal size on a mixed background containing BALB/c unlike runted mice on a C57BL/6 inbred background

Allelic Composition	Chrna3^tm1.1Hwrt/Chrna3^tm1.1Hwrt
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna3^tm1.1Hwrt mutation (1 available); any Chrna3 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:157611 )

• average lifespan is similar to on a mixed background containing ICR

nervous system

abnormal action potential ( J:157611 )

• nerve-evoked compound action potentials (CAPs) from the postganglionic trunk in the superior cervical ganglia are smaller than in wild-type mice

• nerve-evoked CAPs are completely blocked by alpha-bungarotoxin unlike in wild-type mice

abnormal excitatory postsynaptic potential ( J:157611 )

• most nerve-evoked excitatory postsynaptic potentials (EPSPs) on sympathetic neurons in the superior cervical ganglia are subthreshold compared to in wild-type mice

• unlike in wild-type mice, nerve evoked EPSPs are blocked by alpha-bungarotoxin

Allelic Composition	Chrna3^tm1.1Hwrt/Chrna3^tm1.1Hwrt
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna3^tm1.1Hwrt mutation (1 available); any Chrna3 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:157611 )

• Background Sensitivity: average lifespan is 5 months on an outbred background compared with less than 3 month on a C57BL/6 inbred background

Allelic Composition	Chrna3^tm1.1Hwrt/Chrna3^tm1.1Hwrt Chrna7^tm1Bay/Chrna7^tm1Bay
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna3^tm1.1Hwrt mutation (1 available); any Chrna3 mutation (35 available)
Chrna7^tm1Bay mutation (1 available); any Chrna7 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal excitatory postsynaptic potential ( J:157611 )

• most nerve-evoked excitatory postpynaptic potentials (EPSPs) on sympathetic neurons in the superior cervical ganglia are subthreshold compared to in wild-type mice

• unlike in wild-type mice, nerve evoked EPSPs are blocked by alpha-bungarotoxin

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