Phenotypes associated with this allele

• Allele Symbol: Chrm4^tm2.1Jwe
• Allele Name: targeted mutation 2.1, Jurgen Wess
• Allele ID: MGI:4442323
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Chrm4^tm2.1Jwe/Chrm4^tm2.1Jwe Tg(Drd1a-cre)AGsc/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:4442324

Genotype
MGI:4442324

cn1

• Allelic Composition: Chrm4^tm2.1Jwe/Chrm4^tm2.1Jwe; Tg(Drd1a-cre)AGsc/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron physiology ( J:157841 )

• the inhibitory effect of carbachol, a hydrolytically stable ACh analog, is not observed in striatal membranes exposed to the D1 receptor agonist, SKF82958.

behavior/neurological

enhanced behavioral response to xenobiotic ( J:157841 )

• enhanced activity at the highest dose (30 ug/kg) of SKF82958, a D1 receptor agonist

enhanced behavioral response to addictive substance ( J:157841 )

• significantly more active following a high dose (2 mg/kg) of amphetamine

• develop enhanced amphetamine induced behavioral sensitization

enhanced behavioral response to cocaine ( J:157841 )

• significantly more active following exposure to a high dose (10 mg/kg) of cocaine

• develop enhanced cocaine induced behavioral sensitization

impaired behavioral response to xenobiotic ( J:157841 )

• haloperidol induced and risperidone induced catalepsy are attenuated

hyperactivity ( J:157841 )

• enhanced activity at the highest dose of SKF82958, a D1 receptor agonist

• enhanced activity at high doses of cocaine (10 mg/kg) or amphetamine (2 mg/kg)

catalepsy ( J:157841 )

• haloperidol induced and risperidone induced catalepsy are attenuated

homeostasis/metabolism

increased dopamine level ( J:157841 )

• basal dopamine efflux in the nucleus accumbens of is increased two- to three-fold

• absolute amphetamine-induced dopamine efflux was significantly enhanced at the 120 min time point, as compared to control mice

• however, the relative percent increase induced by amphetamine exposure is not different from controls