Phenotypes associated with this allele

• Allele Symbol: Pten^tm1.2Mwst
• Allele Name: targeted mutation 1.2, Michael Weinstein
• Allele ID: MGI:4442327
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pten^tm1.2Mwst/Pten^tm1.2Mwst	involves: 129S6/SvEvTac * Black Swiss * FVB/N	MGI:4442328
ht2	Pten^tm1.2Mwst/Pten^+	involves: 129S6/SvEvTac * Black Swiss * FVB/N	MGI:6512404

Genotype
MGI:4442328

hm1

• Allelic Composition: Pten^tm1.2Mwst/Pten^tm1.2Mwst
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:158751 )

• resorption by E9.5

embryo

abnormal gastrulation ( J:158751 )

• failure of axial rotation

abnormal rostral-caudal axis patterning ( J:158751 )

• defects in anterior-posterior patterning

abnormal embryonic tissue morphology ( J:158751 )

• absence of overt tissue differentiation

Genotype
MGI:6512404

ht2

• Allelic Composition: Pten^tm1.2Mwst/Pten⁺
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

reproductive system

increased prostate gland tumor incidence ( J:158751 )

♂ • 93.3% of mice develop proliferative lesions of the prostate

♂ • increased coincidence with stomach tumors

increased uterus carcinoma incidence ( J:158751 )

♀ • proliferative lesions of the endometrium, simple hyperplasia and atypical hyperplasia

♀ • increased coincidence with lymph node neoplasms

endometrium hyperplasia ( J:158751 )

♀ • proliferative lesions of the endometrium, simple hyperplasia and atypical hyperplasia

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:158751 )

• 19.1% of 9 month old mice develop proliferative lesions of the intestine

increased stomach tumor incidence ( J:158751 )

• increased coincidence of stomach tumors with prostate neoplasms

neoplasm

increased gastrointestinal tumor incidence ( J:158751 )

• 19.1% of 9 month old mice develop proliferative lesions of the intestine

increased stomach tumor incidence ( J:158751 )

• increased coincidence of stomach tumors with prostate neoplasms

increased adrenal gland tumor incidence ( J:158751 )

• in 76.5% of 9 month old mice, with a male bias

increased thyroid tumor incidence ( J:158751 )

• 76.3% of 9 month old mice develop proliferative lesions of the thyroid

• increased coincidence of thyroid tumors with lymph node neoplasms

increased mammary gland tumor incidence ( J:158751 )

• mammary intraepithelial neoplasia and invasive carcinoma in female mice

• increased coincidence with lymph node neoplasms in female mice

increased mammary adenoacanthoma incidence ( J:158751 )

• adenosquamous carcinoma in female mice

increased prostate gland tumor incidence ( J:158751 )

♂ • 93.3% of mice develop proliferative lesions of the prostate

♂ • increased coincidence with stomach tumors

increased lymphoma incidence ( J:158751 )

• 58.9% of mice develop proliferative lesions of the lymph node, with a female bias

• increased coincidence with uterine neoplasms

• increased coincidence with mammary gland neoplasms

• increased coincidence of thyroid tumors with lymph node neoplasms

increased T cell derived lymphoma incidence ( J:158751 )

• 55.8% of 9 month old mice develop proliferative lesions of the thymus

increased uterus carcinoma incidence ( J:158751 )

♀ • proliferative lesions of the endometrium, simple hyperplasia and atypical hyperplasia

♀ • increased coincidence with lymph node neoplasms

integument

increased mammary gland tumor incidence ( J:158751 )

• mammary intraepithelial neoplasia and invasive carcinoma in female mice

• increased coincidence with lymph node neoplasms in female mice

increased mammary adenoacanthoma incidence ( J:158751 )

• adenosquamous carcinoma in female mice

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:158751 )

• in 76.5% of 9 month old mice, with a male bias

increased T cell derived lymphoma incidence ( J:158751 )

• 55.8% of 9 month old mice develop proliferative lesions of the thymus

increased thyroid tumor incidence ( J:158751 )

• 76.3% of 9 month old mice develop proliferative lesions of the thyroid

• increased coincidence of thyroid tumors with lymph node neoplasms

increased mammary gland tumor incidence ( J:158751 )

• mammary intraepithelial neoplasia and invasive carcinoma in female mice

• increased coincidence with lymph node neoplasms in female mice

increased mammary adenoacanthoma incidence ( J:158751 )

• adenosquamous carcinoma in female mice

increased prostate gland tumor incidence ( J:158751 )

♂ • 93.3% of mice develop proliferative lesions of the prostate

♂ • increased coincidence with stomach tumors

immune system

increased T cell derived lymphoma incidence ( J:158751 )

• 55.8% of 9 month old mice develop proliferative lesions of the thymus

hematopoietic system

increased T cell derived lymphoma incidence ( J:158751 )

• 55.8% of 9 month old mice develop proliferative lesions of the thymus

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Cowden syndrome		DOID:6457	OMIM:PS158350	J:158751