Phenotypes associated with this allele

• Allele Symbol: Arhgef1^tm1Rmt
• Allele Name: targeted mutation 1, Raul M Torres
• Allele ID: MGI:4442362
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Arhgef1^tm1Rmt/Arhgef1^tm1Rmt X/Tg(Myh11-icre/ERT2)1Soff	involves: C57BL/6 * FVB/N	MGI:4442363

Genotype
MGI:4442363

cn1

• Allelic Composition: Arhgef1^tm1Rmt/Arhgef1^tm1Rmt; X/Tg(Myh11-icre/ERT2)1Soff
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aorta wall morphology ( J:157074 )

♂ • arterial wall remodeling in response to Angiotensin II treatment is absent

cardiac hypertrophy ( J:157074 )

♂ • cardiac hypertrophy, as assessed by the heart to body weight ratio, is significantly reduced in mice treated with both tamoxifen and Angiotensin II

abnormal systemic arterial blood pressure ( J:157074 )

♂ • Angiotensin II or N-nitro-l-arginine (L-NAME) treatment do not increase blood pressure in tamoxifen treated mice

♂ • tamoxifen treatment starting 10 days after the beginning of Angiotensin II treatment is able to reverse Angiotensin II induced hypertension

♂ • mice treated with deoxycorticosterone acetate plus NaCl are not completely protected from induced hypertension and are resistant to the blood pressure-lowering effects of the subsequent treatment with an Angiotensin II type 1 receptor antagonist

decreased vasoconstriction ( J:157074 )

♂ • the amplitude of Angiotensin II induced contractions was much lower in the ex vivo aortic rings, from tamoxifen treated mice

♂ • in tamoxifen treated mice the in vivo response to Angiotensin II is reduced

muscle

decreased vasoconstriction ( J:157074 )

♂ • the amplitude of Angiotensin II induced contractions was much lower in the ex vivo aortic rings, from tamoxifen treated mice

♂ • in tamoxifen treated mice the in vivo response to Angiotensin II is reduced

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:157074 )

♂ • N-nitro-l-arginine (L-NAME) does not induce hypertension in tamoxifen treated mice

♂ • mice treated with deoxycorticosterone acetate plus NaCl are not completely protected from induced hypertension and are resistant to the blood pressure-lowering effects of the subsequent treatment with an Angiotensin II type 1 receptor antagonist

growth/size/body

cardiac hypertrophy ( J:157074 )

♂ • cardiac hypertrophy, as assessed by the heart to body weight ratio, is significantly reduced in mice treated with both tamoxifen and Angiotensin II