Phenotypes associated with this allele

• Allele Symbol: Slc32a1^tm1.1Bgc
• Allele Name: targeted mutation 1.1, Brian G Condie
• Allele ID: MGI:4442415
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc32a1^tm1.1Bgc/Slc32a1^tm1.1Bgc	involves: 129X1/SvJ	MGI:4442417

Genotype
MGI:4442417

hm1

• Allelic Composition: Slc32a1^tm1.1Bgc/Slc32a1^tm1.1Bgc
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cleft palate and umbilical hernia in Slc32a1^tm1.1Bgc/Slc32a1^tm1.1Bgc mice

mortality/aging

perinatal lethality, complete penetrance ( J:158888 )

• die at or immediately before birth

respiratory system

respiratory failure ( J:158888 )

• all newborns fail to breath

craniofacial

cleft secondary palate ( J:158888 )

• at P0

• injection of pregnant dams with muscimol (a GABA agonist) partially rescues the cleft palate phenotype

failure of palatal shelf elevation ( J:158888 )

• at E14.5

• however, in culture palatal explants are able to undergo elevation and fusion

embryo

umbilical hernia ( J:158888 )

• umbilical hernia is seen in nearly all (98%) pups at P0

behavior/neurological

hunched posture ( J:158888 )

• at P0

adipose tissue

abnormal adipose tissue distribution ( J:158888 )

• at P0, display small subcutaneous bumps in the dorsal cervical region that appear to be clumps of displaced brown fat

digestive/alimentary system

cleft secondary palate ( J:158888 )

• at P0

• injection of pregnant dams with muscimol (a GABA agonist) partially rescues the cleft palate phenotype

failure of palatal shelf elevation ( J:158888 )

• at E14.5

• however, in culture palatal explants are able to undergo elevation and fusion

growth/size/body

cleft secondary palate ( J:158888 )

• at P0

• injection of pregnant dams with muscimol (a GABA agonist) partially rescues the cleft palate phenotype

failure of palatal shelf elevation ( J:158888 )

• at E14.5

• however, in culture palatal explants are able to undergo elevation and fusion